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VTP-27999 (Hydrochloride)

Names

[ CAS No. ]:
1264191-73-2

[ Name ]:
VTP-27999 (Hydrochloride)

[Synonym ]:
VTP-27999 (Hydrochloride)

Biological Activity

[Description]:

VTP-27999 Hcl is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.IC50 value:Target: Renin

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Renin
Research Areas >> Cardiovascular Disease

[References]

[1]. Lanqi Jia et al. Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility ACS Med. Chem. Lett., 2011, 2 (10), pp 747-751

[2]. New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin. Hypertension. 2013 May;61(5):1075-1082.

[3]. Ishchenko A, et al. Structure-based design technology contour and its application to the design of Renin inhibitors.J Chem Inf Model. 2012 Aug 27;52(8):2089-97. Epub 2012 Jul 25.


[Related Small Molecules]

VTP 27999 trifluoroacetate | ACT 178882 | Handle region peptide, rat

Chemical & Physical Properties

[ Molecular Formula ]:
C26H42Cl2N4O5

[ Molecular Weight ]:
561.54100

[ Exact Mass ]:
560.25300

[ PSA ]:
108.14000

[ LogP ]:
5.11960

[ Storage condition ]:
2-8℃

Related Compounds