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VTP 27999 trifluoroacetate

Names

[ CAS No. ]:
1013937-63-7

[ Name ]:
VTP 27999 trifluoroacetate

[Synonym ]:
methyl 2-((R)-(3-chlorophenyl)((R)-1-((S)-2-(methylamino)-3-((R)-tetrahydro-2H-pyran-3-yl)propylcarbamoyl)piperidin-3-yl)methoxy)ethylcarbamate trifluoroacetate
CS-0312
methyl {2-[((R)-(3-chlorophenyl){(3R)-1-[({(2S)-2-(methyl-amino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl}amino)carbonyl]-3-piperidinyl}methyl)oxy]ethyl}carbamate trifluoroacetate
VTP-27999 (2,2,2-trifluoroacetate)

Biological Activity

[Description]:

VTP-27999 2,2,2-trifluoroacetate is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.Ic50 value:Target: Renin

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Renin
Research Areas >> Cardiovascular Disease

[References]

[1]. New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin. Hypertension. 2013 May;61(5):1075-1082.

[2]. Lanqi Jia? et al. Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility ACS Med. Chem. Lett., 2011, 2 (10), pp 747-751

[3]. Ishchenko A, et al. Structure-based design technology contour and its application to the design of Renin inhibitors.J Chem Inf Model. 2012 Aug 27;52(8):2089-97. Epub 2012 Jul 25.


[Related Small Molecules]

VTP-27999 (Hydrochloride) | ACT 178882 | Handle region peptide, rat

Chemical & Physical Properties

[ Molecular Formula ]:
C28H42ClF3N4O7

[ Molecular Weight ]:
639.10400

[ Exact Mass ]:
638.26900

[ PSA ]:
138.46000

[ LogP ]:
5.32390

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds