ROCK-IN-1

Names

[ CAS No. ]:
934387-35-6

[ Name ]:
ROCK-IN-1

Biological Activity

[Description]:

ROCK-IN-1 is a potent inhibitor of ROCK, with an IC50 of 1.2 nM for ROCK2.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK
Signaling Pathways >> Stem Cell/Wnt >> ROCK
Signaling Pathways >> TGF-beta/Smad >> ROCK
Research Areas >> Inflammation/Immunology
Research Areas >> Cardiovascular Disease

[Target]

ROCK2:1.2 nM (IC50)


[In Vitro]

ROCK-IN-1 shows potent cellular efficacy, with an EC50 of 200 nM[1].

[References]

[1]. Boland S, et al. 3-[2-(Aminomethyl)-5-[(pyridin-4-yl)carbamoyl]phenyl] benzoates as soft ROCK inhibitors. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6442-6.


[Related Small Molecules]

Y-27632 2HCl | Fasudil Hydrochloride | KD025(SLx-2119) | Narciclasine | Y-39983 HCl | Thiazovivin | GSK429286A | GSK180736A | GSK 269962 | SR-3677 | TC-S 7001 | K-115 | RKI-1447 | LX7101 | Chroman 1

Chemical & Physical Properties

[ Molecular Formula ]:
C20H18FN3O

[ Molecular Weight ]:
335.37

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds