ROCK-IN-5

Names

[ CAS No. ]:
692870-25-0

[ Name ]:
ROCK-IN-5

[Synonym ]:
Benzeneacetamide, 2-chloro-6-fluoro-N-[4-(4-pyridinyl)-2-thiazolyl]-
2-(2-Chloro-6-fluorophenyl)-N-[4-(4-pyridinyl)-1,3-thiazol-2-yl]acetamide

Biological Activity

[Description]:

ROCK-IN-5 (compound I-B-37) is a potent inhibitor of ROCK, ERK, GSK, and AGC protein kinases. ROCK-IN-5 has the potential for proliferative, cardiac and neurodegenerative diseases research[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> GSK-3
Research Areas >> Cardiovascular Disease
Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK
Signaling Pathways >> MAPK/ERK Pathway >> ERK
Research Areas >> Neurological Disease
Signaling Pathways >> Stem Cell/Wnt >> ROCK
Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
Signaling Pathways >> TGF-beta/Smad >> ROCK
Signaling Pathways >> Stem Cell/Wnt >> ERK

[References]

[1]. Jingrong Cao, et al. Compositions useful as inhibitors of rock and other protein kinases. WO2004041813A1.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C16H11ClFN3OS

[ Molecular Weight ]:
347.79

[ Exact Mass ]:
347.029541

[ LogP ]:
3.11

[ Index of Refraction ]:
1.662

Related Compounds