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SIRT6-IN-5

Names

[ CAS No. ]:
891002-11-2

[ Name ]:
SIRT6-IN-5

[Synonym ]:
5-{[4-(2-Furoylamino)benzoyl]amino}-2-hydroxybenzoic acid
MFCD07114223
Benzoic acid, 5-[[4-[(2-furanylcarbonyl)amino]benzoyl]amino]-2-hydroxy-

Biological Activity

[Description]:

SIRT6-IN-2 (Compound 5) is a selective SIRT6 inhibitor (IC50: 34 μM). SIRT6-IN-2 increases acetylation of H3K9 and increases glucose uptake in cultured cells. SIRT6-IN-2 also reduces T cell proliferation. SIRT6-IN-2 has immunosuppressive and chemosensitizing effects[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Sirtuin
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin

[Target]

SIRT6[1]


[References]

[1]. Damonte P, et al. SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects. Bioorg Med Chem. 2017 Oct 15;25(20):5849-5858.  

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
461.6±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H14N2O6

[ Molecular Weight ]:
366.32

[ Flash Point ]:
233.0±28.7 °C

[ Exact Mass ]:
366.085175

[ LogP ]:
3.39

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.733

Related Compounds