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hCAIX-IN-5

Names

[ CAS No. ]:
2451479-57-3

[ Name ]:
hCAIX-IN-5

Biological Activity

[Description]:

hCAIX-IN-5 (compound 6b) is a potent and selective hCAIX inhibitor with KIs of >10000, >10000, 130.7, 829.1 nM for hCAI, hCAII, hCAIV, hCAIX, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase

[Target]

KI: >10000 nM (hCAI); >10000 nM (hCAII); 130.7 nM (hCAIV); 829.1 nM (hCAIX)[1]


[References]

[1]. Swain B, et al. New coumarin/sulfocoumarin linked phenylacrylamides as selective transmembrane carbonic anhydrase inhibitors: Synthesis and in-vitro biological evaluation. Bioorg Med Chem. 2020 Aug 1;28(15):115586.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H12FNO3

[ Molecular Weight ]:
309.29

Related Compounds