Metorphamide

Names

[ Name ]:
Metorphamide

[Synonym ]:
H-TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-NH2
METORPHINAMIDE
METORPHAMIDE
PROENKEPHALIN (206-213) (BOVINE)
adrenorphin amide
TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-NH2
METORPHIN
tyr-gly-gly-phe-met-arg-arg-val amide

Biological Activity

[Description]:

Adrenorphin is a opioid octapeptide, acting as a potent agonist of μ-opioid receptor, with Ki of 12 nM.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor

Signaling Pathways >> Neuronal Signaling >> Opioid Receptor

Research Areas >> Cancer

Peptides

[Target]

Ki: 12 nM (μ-opioid receptor)[1]

[In Vitro]

Adrenorphin (Metorphamide) is a opioid octapeptide from bovine brain, acts as a potent agonist of μ-opioid receptor, with Ki of 12 nM. The binding ratios of Ki for μ-opioid receptor/Ki for δ-opioid receptor of 0.04 and of Ki for μ-opioid receptor/Ki for κ-opioid receptor of 0.46[1]. Adrenorphin potently inhibits catecholamine secretion evoked by 10 μM nicotine in cultured human pheochromocytoma 6 cells, with an IC50 of 1.1 μM[2].

[References]

[1]. Weber E, et al. Metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain. Proc Natl Acad Sci U S A. 1983 Dec;80(23):7362-6.

[2]. Yanase T, et al. Studies on adrenorphin in pheochromocytoma. J Clin Endocrinol Metab. 1987 Apr;64(4):692-7.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.42g/cm3

[ Molecular Formula ]:
C₄₄H₆₉N₁₅O₉S

[ Molecular Weight ]:
984.17900

[ Exact Mass ]:
983.51200

[ PSA ]:
442.14000

[ LogP ]:
3.10080

[ Index of Refraction ]:
1.656

[ Storage condition ]:
2-8℃

Safety Information

[ WGK Germany ]:
3

Related Compounds

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