4,4'-Dithiobis[2-aminobutyric Acid]

Names

[ CAS No. ]:
870-93-9

[ Name ]:
4,4'-Dithiobis[2-aminobutyric Acid]

[Synonym ]:
H-DL-Hcys-OH)2
Dl-Homocycine
EINECS 207-323-8
homocystine
4,4'-Disulfanediylbis(2-aminobutanoic acid)
MFCD00069587
4,4'-Disulfanediylbis(2-aminobutansäure)
Butanoic acid, 4,4'-dithiobis[2-amino-
dl-homocystine crystalline
HOMOCYSTINE,DL
4,4'-Dithiobis[2-aminobutanoic Acid]
4,4'-Dithiobis[2-aminobutyric Acid]

Biological Activity

[Description]:

DL-Homocystine is the double-bonded form of homocysteine and homocysteine is recognized as an important substance in the pathogenesis and pathophysiology of schizophrenia.

[Related Catalog]:

Research Areas >> Metabolic Disease

Natural Products >> Others

[Target]

Human Endogenous Metabolite

[References]

[1]. Brown AS, et al. Homocysteine and schizophrenia: from prenatal to adult life. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Sep;29(7):1175-80.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
507.6±50.0 °C at 760 mmHg

[ Melting Point ]:
≥300 °C

[ Molecular Formula ]:
C₈H₁₆N₂O₄S₂

[ Molecular Weight ]:
268.354

[ Flash Point ]:
260.8±30.1 °C

[ Exact Mass ]:
268.055145

[ PSA ]:
177.24000

[ LogP ]:
1.03

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.619

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2930909090

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Determination of homocysteine in cerebrospinal fluid as an indicator for surgery treatment in patients with hydrocefalus.

Physiol. Res. 63(4) , 521-7, (2014)

Increased homocysteine levels in serum are typical features of neurodegenerative brain diseases including hydrocephalus. The most frequent therapeutic approach consists of the insertion of a shunt, co...

Simultaneous determination of cystathionine, total homocysteine, and methionine in dried blood spots by liquid chromatography/tandem mass spectrometry and its utility for the management of patients with homocystinuria.

Clin. Chim. Acta 437 , 211-7, (2014)

Disorders of homocysteine and B-vitamin metabolism represent a significant problem in clinical practice. Establishing the diagnosis requires specialized tests with demanding preanalytical requirements...

Excess levels of cysteine and homocysteine induce tibial dyschondroplasia in broiler chicks.

J. Nutr. 122 , 482-487, (1992)

The effect of excessive levels of cysteine and homocysteine on tibial dyschondroplasia (TD) in broiler chicks was studied. In the first experiment, graded levels of L-cysteine as well as one level of ...