7-Ethyl-10-hydroxycamptothecin
Names
[ CAS No. ]:
86639-52-3
[ Name ]:
7-Ethyl-10-hydroxycamptothecin
[Synonym ]:
7-Ethyl-10-Hydroxycamptothecin(SN-38)
(4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-, (4S)-
SN-38
MFCD06762720
SN38
7-Ethyl-10-hydroxycamptothecine
Biological Activity
[Description]:
[Related Catalog]:
[Target]
Topoisomerase I
[In Vitro]
[In Vivo]
[Kinase Assay]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Boiling Point ]:
810.3±65.0 °C at 760 mmHg
[ Melting Point ]:
217 °C
[ Molecular Formula ]:
C22H20N2O5
[ Molecular Weight ]:
392.405
[ Flash Point ]:
443.8±34.3 °C
[ Exact Mass ]:
392.137207
[ PSA ]:
101.65000
[ LogP ]:
2.31
[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C
[ Index of Refraction ]:
1.738
[ Storage condition ]:
−20°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UQ0491000
- CAS REGISTRY NUMBER :
- 86639-52-3
- LAST UPDATED :
- 199203
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C22-H20-N2-O5
- MOLECULAR WEIGHT :
- 392.44
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Rodent - mouse Leukocyte
- DOSE/DURATION :
- 1 umol/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 51,4187,1991
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301
[ Precautionary Statements ]:
P301 + P310
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
T
[ Risk Phrases ]:
25
[ Safety Phrases ]:
45
[ RIDADR ]:
UN 2811 6.1 / PGIII
[ RTECS ]:
UQ0491000
[ HS Code ]:
2942000000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2942000000
Articles
Food Chem. Toxicol. 72 , 13-9, (2014)
In this study, we evaluated inhibitory potentials of popularly-consumed berries (bilberry, blueberry, cranberry, elderberry, and raspberry ketones) as herbal supplements on UGT1A1, UGT1A4, UGT1A6, UGT...
Evaluation of thein vitro/in vivodrug interaction potential of BST204, a purified dry extract of ginseng, and its four bioactive ginsenosides through cytochrome P450 inhibition/induction and UDP-glucuronosyltransferase inhibitionFood Chem. Toxicol. 68 , 117-27, (2014)
• BST204 is a purified dry extract of ginseng containing high amounts of Rh2 and Rg3. • BST204 had only weak inhibitory effects on nine CYPs and five UGTs. • It is unlikely that BST204 alter pharmacok...
Nanoparticle delivery of an SN38 conjugate is more effective than irinotecan in a mouse model of neuroblastoma.Cancer Lett. 360(2) , 205-12, (2015)
Neuroblastoma (NB) is the most common and deadly solid tumor in children. The majority of NB patients have advanced stage disease with poor prognosis, so more effective, less toxic therapy is needed. ...