7-Ethylcamptothecin

Names

[ Name ]:
7-Ethylcamptothecin

[Synonym ]:
SN 22
(4S)-4,11-Diethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4-hydroxy-, (S)-
20(S)-7-ethylcamptothecin
(S)-4,11-Diethyl-4-hydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione
7-ethyl-20(S)-camptothecin
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4-hydroxy-, (4S)-

Biological Activity

[Description]:

7-Ethylcamptothecin is one of camptothecin analogues. camptothecin (CPT), a cytotoxic alkaloid isolated from Camptotheca acuminate, is shown to have strong antitumor activity against L1210 leukemia and Walker 256 carcinosarcoma models[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Wang, X.,et al. New Route for Conversion of Camptothecin to 7-Ethylcamptothecin and 7-Propylcamptothecin. Synthetic Communications, 2007,37(3), 519–523.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
752.9±60.0 °C at 760 mmHg

[ Melting Point ]:
236-241ºC

[ Molecular Formula ]:
C₂₂H₂₀N₂O₄

[ Molecular Weight ]:
376.405

[ Flash Point ]:
409.1±32.9 °C

[ Exact Mass ]:
376.142303

[ PSA ]:
81.42000

[ LogP ]:
2.60

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.713

[ Storage condition ]:
-20°C Freezer

MSDS

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Safety Information

[ Hazard Codes ]:
T+

[ HS Code ]:
2942000000

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2942000000

Related Compounds

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