12-Ethyl-9-hydroxycamptothecin

Names

[ CAS No. ]:
119577-28-5

[ Name ]:
12-Ethyl-9-hydroxycamptothecin

[Synonym ]:
(4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-, (4S)-
SN-38
SN38
7-Ethyl-10-hydroxycamptothecine
(4S)-4,11-DIETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7] INDOLIZINO [1,2-B] QUINOLINE-3,14 (4H,12H)-DIONE

Biological Activity

[Description]:

12-Ethyl-9-hydroxycamptothecin is a derivative of Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

12-Ethyl-9-hydroxycamptothecin is a derivative of Camptothecin.

[References]

[1]. Luzzio MJ, et al. Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I. J Med Chem. 1995;38(3):395-401.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
810.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₀N₂O₅

[ Molecular Weight ]:
392.40

[ Flash Point ]:
443.8±34.3 °C

[ Exact Mass ]:
392.137207

[ PSA ]:
101.65000

[ LogP ]:
2.31

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.738

[ Storage condition ]:
2-8C

Safety Information

[ HS Code ]:
2942000000

Customs

[ HS Code ]: 2942000000