Amonafide
Names
[ CAS No. ]:
69408-81-7
[ Name ]:
Amonafide
[Synonym ]:
Amonifide
5-amino-2-[(dimethylamine)ethyl]-1H-benz[de-]isoquinoline-1,3-(2H)-dione
amonafide
1H-Benz[de]isoquinoline-1,3(2H)-dione, 5-amino-2-[2-(dimethylamino)ethyl]-
AS-1413
5-Aminomitonafide
Nafidimide
Benzisoquinolinedione
Quinamed
Amonafidum [Latin]
5-Amino-2-[2-(dimethylamino)ethyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione
2-(2-dimethylaminoethyl)-5-aminobenzo[de]isoquinoline-1,3-dione
5-amino-2-(2-(dimethylamino)ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
Xanafide
Biological Activity
[Description]:
[Related Catalog]:
[Target]
Topoisomerase II
[In Vitro]
[Cell Assay]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
500.2±35.0 °C at 760 mmHg
[ Melting Point ]:
162-164ºC
[ Molecular Formula ]:
C16H17N3O2
[ Molecular Weight ]:
283.325
[ Flash Point ]:
256.3±25.9 °C
[ Exact Mass ]:
283.132080
[ PSA ]:
68.33000
[ LogP ]:
0.06
[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C
[ Index of Refraction ]:
1.681
[ Storage condition ]:
-20°C Freezer
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QK5610000
- CHEMICAL NAME :
- Naphthalimide, 3-amino-N-(2-(dimethylamino)ethyl)-
- CAS REGISTRY NUMBER :
- 69408-81-7
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C16-H17-N3-O2
- MOLECULAR WEIGHT :
- 283.36
- WISWESSER LINE NOTATION :
- T666 1A M CVNVT&&J D2N1&1 HZ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 67 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >18400 ug/kg
- TOXIC EFFECTS :
- Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands
MUTATION DATA
- TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Rodent - mouse Leukocyte
- DOSE/DURATION :
- 50 umol/L
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 34,3845,1985