Phthalylsulfathiazole

Names

[ CAS No. ]:
85-73-4

[ Name ]:
Phthalylsulfathiazole

[Synonym ]:
Cremothalidine
Phthalylsulfathiazole
Taloudron
Ftalazol
2-[({4-[(1,3-thiazol-2-ylamino)sulfonyl]phenyl}amino)carbonyl]benzoic acid
N-(4-thiazol-2-ylsulfamoyl-phenyl)-phthalamic acid
Talidine
entexidin
Phtalazol
N-(4-Thiazol-2-ylsulfamoyl-phenyl)-phthalamidsaeure
EINECS 201-627-4
Benzoic acid, 2-[[[4-[(2-thiazolylamino)sulfonyl]phenyl]amino]carbonyl]-
Sulftalyl
PST
2-[({4-[(2-thiazolylamino)sulfonyl]phenyl}amino)carbonyl]-benzoic acid
Thalinil
Ftalysept
2-{[4-(1,3-Thiazol-2-ylsulfamoyl)phenyl]carbamoyl}benzoic acid
MFCD00005318
Taleudron

Biological Activity

[Description]:

Phthalylsulfathiazole is a kind of sulfonamides used as an antibacterial drug.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial

Research Areas >> Others

[References]

[1]. S. RAGHAV, et al. Kinetics of Xylene Coagulation in Water Emulsion Stabilized by Phthalylsulfathiazole. ACS Symposium Series, 1985: 447-460

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
579ºC at 760 mmHg

[ Melting Point ]:
198-204°C

[ Molecular Formula ]:
C₁₇H₁₃N₃O₅S₂

[ Molecular Weight ]:
403.432

[ Flash Point ]:
304ºC

[ Exact Mass ]:
403.029663

[ PSA ]:
162.08000

[ LogP ]:
1.54

[ Index of Refraction ]:
1.715

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TH8575000

CHEMICAL NAME :: Phthalanilic acid, 4'-(2-thiazolylsulfamoyl)-

CAS REGISTRY NUMBER :: 85-73-4

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C17-H13-N3-O5-S2

MOLECULAR WEIGHT :: 403.45

WISWESSER LINE NOTATION :: T5N CSJ BMSWR DMVR BVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(12),9,1993

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,116,1944

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 920 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,116,1944 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12900 mg/kg/30D-I

TOXIC EFFECTS :: Gastrointestinal - changes in structure or function of esophagus

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(12),9,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84641 No. of Facilities: 193 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 9471 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84641 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 94 (estimated) No. of Female Employees: 62 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
3249

[ RTECS ]:
TH8575000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Articles

[Experimental basis for the tentative permissible levels of phthalazol, sulfadimethoxine and Bepask in bodies of water].

Gig. Sanit. (12) , 9-10, (1993)

Tentative permissible levels (TPL) of phthalazol, sulfadimethoxine, and Bepask in the water were substantiated on the basis of study of organoleptic properties, of influence on sanitary status of wate...

The effect of antibacterial agents on the intestinal flora of patients: the use of aureomycin, chloromycetin, dihydrostreptomycin, sulfasuxidine and sulfathalidine.

Gastroenterology 16(1) , 12-8, (1950)

The effects of phthalylsulphathiazole on the bacteria of the colonic mucosa and intestinal contents as revealed by the examination of surgical samples.

Scand. J. Gastroenterol. 14(7) , 891-6, (1979)

The isolation of a bacterial flora specifically associated with the colonic mucosa of patients undergoing large-bowel surgery is described. This flora differed from that of faeces in both the numbers ...