2-Phenyl-isoindole-1,3-dione
Names
[ CAS No. ]:
520-03-6
[ Name ]:
2-Phenyl-isoindole-1,3-dione
[Synonym ]:
EINECS 208-282-9
2-Phenyl-1H-isoindole-1,3(2H)-dione
1H-Isoindole-1,3(2H)-dione, 2-phenyl-
2-Phenylisoindole-1,3-dione
2-Phenyl-isoindole-1,3-dione
MFCD00023044
N-PHENYLPHTHALIMIDE
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
388.8±25.0 °C at 760 mmHg
[ Melting Point ]:
204-207 °C(lit.)
[ Molecular Formula ]:
C14H9NO2
[ Molecular Weight ]:
223.227
[ Flash Point ]:
182.6±15.5 °C
[ Exact Mass ]:
223.063324
[ PSA ]:
37.38000
[ LogP ]:
2.40
[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C
[ Index of Refraction ]:
1.667
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TI5635800
- CHEMICAL NAME :
- Phthalimide, N-phenyl-
- CAS REGISTRY NUMBER :
- 520-03-6
- BEILSTEIN REFERENCE NO. :
- 0010683
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C14-H9-N-O2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,23,1953
Safety Information
[ Safety Phrases ]:
S22-S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
TI5635800
[ HS Code ]:
2925190090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2925190090
[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
Articles
J. Med. Chem. 54 , 5454, (2011)
To identify specific bacterial thymidylate synthase (TS) inhibitors, we exploited phenolphthalein (PTH), which inhibits both bacterial and human enzymes. The X-ray crystal structure of Lactobacillus c...
Phenylphthalimides with tumor necrosis factor alpha production-enhancing activity.Chem. Pharm. Bull. 44(1) , 156-62, (1996)
Phenylphthalimides (2-phenyl-1H-isoindole-1,3-diones) were prepared and their effects on tumor necrosis factor alpha (TNF-alpha) production by human leukemia cell line HL-60 stimulated with 12-O-tetra...
Nonpeptide small-molecular inhibitors of dipeptidyl peptidase IV: N-phenylphthalimide analogs.Bioorg. Med. Chem. Lett. 9(4) , 559-62, (1999)
A novel series of nonpeptide small-molecular dipeptidyl peptidase IV (DPP-IV) inhibitors with an N-phenylphthalimide skeleton has been developed. Some of the compounds, including 4-amino-(2,6-dimethyl...