Melanin

[Description]:

Melanin is a unique pigment with myriad functions. It is multifunctional, providing defense against environmental stresses such as ultraviolet (UV) light, oxidizing agents and ionizing radiation.

[Related Catalog]:

Natural Products >> Others

Research Areas >> Others

[Target]

Human Endogenous Metabolite

[In Vitro]

Melanin contributes to the ability of fungi to survive in harsh environments. In addition, it plays a role in fungal pathogenesis. Melanin is an amorphous polymer that is produced by one of two synthetic pathways. Fungi may synthesize melanin from endogenous substrate via a 1,8-dihydroxynaphthalene (DHN) intermediate. Alternatively, some fungi produce melanin from L-3,4-dihydroxyphenylalanine (L-dopa)[1].

[References]

[1]. Eisenman HC, et al. Synthesis and assembly of fungal melanin. Appl Microbiol Biotechnol. 2012 Feb;93(3):931-40.

[Related Small Molecules]

[ Density]:
1.65g/cm3

[ Boiling Point ]:
500.5ºC at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₀N₂O₄

[ Molecular Weight ]:
318.28300

[ Flash Point ]:
195.4ºC

[ Exact Mass ]:
318.06400

[ PSA ]:
99.86000

[ LogP ]:
1.32660

[ Index of Refraction ]:
1.771

[ Storage condition ]:
-20°C

Click to get detail MSDS

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ HS Code ]:
3203001990

[ HS Code ]: 3203001990

Testing in mice the hypothesis that melanin is protective in malaria infections.

PLoS ONE 7 , e29493, (2012)

Malaria has had the largest impact of any infectious disease on shaping the human genome, exerting enormous selective pressure on genes that improve survival in severe malaria infections. Modern human...

Identification of quinolines that inhibit melanogenesis by altering tyrosinase family trafficking.

Mol. Pharmacol. 74 , 1576-86, (2009)

A series of quinolines, including chloroquine and quinine, were identified as potent pigmentation inhibitors through screening a compound library in murine melanocytes. Structure-activity relationship...

Ex vivomodels to evaluate the role of ocular melanin in trans-scleral drug delivery

Eur. J. Pharm. Sci. 46(5) , 475-83, (2012)

Trans-scleral delivery is nowadays considered as a possible way to deliver drugs to the posterior segment of the eye. Despite the potentiality of this administration route, there is a lack of fundamen...

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