(D-Ala2)-Leu-Enkephalin
Names
[ CAS No. ]:
64963-01-5
[ Name ]:
(D-Ala2)-Leu-Enkephalin
[Synonym ]:
N-[N-[N-(N-L-tyrosyl-D-alanyl)glycyl]-L-phenylalanyl]-L-leucine
D-Ala(2)-Leu(5)-Enk
TYR-D-ALA-GLY-PHE-LEU
Leucine, tyrosylalanylglycylphenylalanyl-
D-Ala2,D-Leu5-enkephalin
Tyrosylalanylglycylphenylalanylleucine
D-ALA2-LEU5-ENKEPHALIN
D-(Ala)2-leucine enkephalin
[D-Ala2]-Leucine enkephalin
Tyr-D-Ala-Gly-Phe-Leu
H-TYR-D-ALA-GLY-PHE-LEU-OH
L-Tyr-D-Ala-Gly-L-Phe-L-Leu-OH
(D-ALA2)-LEU-ENKEPHALIN
Tyr-D-Ala-Gly-Phe-Leu-OH
(D-alanine2)leucine enkephalin
Pentapeptide-18
Leuphasyl
[D-Ala2]leucine-enkephalin
Biological Activity
[Description]:
[Related Catalog]:
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
991.9±65.0 °C at 760 mmHg
[ Molecular Formula ]:
C29H39N5O7
[ Molecular Weight ]:
569.649
[ Flash Point ]:
553.7±34.3 °C
[ Exact Mass ]:
569.284973
[ PSA ]:
199.95000
[ LogP ]:
2.42
[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.582
[ Storage condition ]:
−20°C
Safety Information
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
Articles
Biochem. J. 320 , 227-235, (1996)
Rat-1 fibroblasts were transfected with a cDNA encoding the mouse delta opioid receptor. Two separate clones, D2 (which expressed some 6 pmol of the receptor/mg of membrane protein) and DOE (which exp...
Activation of mu- and delta-opioid receptors causes presynaptic inhibition of glutamatergic excitation in neocortical neurons.Anesthesiology 93 , 1053-1063, (2000)
The mechanism underlying the depressant effect of opioids on neuronal activity within the neocortex is still not clear. Three modes of action have been suggested: (1) inhibition by activation of posts...
Direct excitatory opiate effects mediated by non-synaptic actions on rat medial vestibular neurons.Eur. J. Pharmacol. 262 , 99-106, (1994)
Opiates increase firing of rat medial vestibular nucleus neurons. We have attempted to determine the mechanism of these excitatory opiate actions by extracellular recording of neuronal activity with i...