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(D-Ala2)-Leu-Enkephalin

Names

[ CAS No. ]:
64963-01-5

[ Name ]:
(D-Ala2)-Leu-Enkephalin

[Synonym ]:
N-[N-[N-(N-L-tyrosyl-D-alanyl)glycyl]-L-phenylalanyl]-L-leucine
D-Ala(2)-Leu(5)-Enk
TYR-D-ALA-GLY-PHE-LEU
Leucine, tyrosylalanylglycylphenylalanyl-
D-Ala2,D-Leu5-enkephalin
Tyrosylalanylglycylphenylalanylleucine
D-ALA2-LEU5-ENKEPHALIN
D-(Ala)2-leucine enkephalin
[D-Ala2]-Leucine enkephalin
Tyr-D-Ala-Gly-Phe-Leu
H-TYR-D-ALA-GLY-PHE-LEU-OH
L-Tyr-D-Ala-Gly-L-Phe-L-Leu-OH
(D-ALA2)-LEU-ENKEPHALIN
Tyr-D-Ala-Gly-Phe-Leu-OH
(D-alanine2)leucine enkephalin
Pentapeptide-18
Leuphasyl
[D-Ala2]leucine-enkephalin

Biological Activity

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
991.9±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C29H39N5O7

[ Molecular Weight ]:
569.649

[ Flash Point ]:
553.7±34.3 °C

[ Exact Mass ]:
569.284973

[ PSA ]:
199.95000

[ LogP ]:
2.42

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.582

[ Storage condition ]:
−20°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Agonist activation of p42 and p44 mitogen-activated protein kinases following expression of the mouse delta opioid receptor in Rat-1 fibroblasts: effects of receptor expression levels and comparisons with G-protein activation.

Biochem. J. 320 , 227-235, (1996)

Rat-1 fibroblasts were transfected with a cDNA encoding the mouse delta opioid receptor. Two separate clones, D2 (which expressed some 6 pmol of the receptor/mg of membrane protein) and DOE (which exp...

Activation of mu- and delta-opioid receptors causes presynaptic inhibition of glutamatergic excitation in neocortical neurons.

Anesthesiology 93 , 1053-1063, (2000)

The mechanism underlying the depressant effect of opioids on neuronal activity within the neocortex is still not clear. Three modes of action have been suggested: (1) inhibition by activation of posts...

Direct excitatory opiate effects mediated by non-synaptic actions on rat medial vestibular neurons.

Eur. J. Pharmacol. 262 , 99-106, (1994)

Opiates increase firing of rat medial vestibular nucleus neurons. We have attempted to determine the mechanism of these excitatory opiate actions by extracellular recording of neuronal activity with i...


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