(D-Ala2)-Leu-Enkephalin
(D-Ala2)-Leu-Enkephalin structure
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Common Name | (D-Ala2)-Leu-Enkephalin | ||
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| CAS Number | 64963-01-5 | Molecular Weight | 569.649 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 991.9±65.0 °C at 760 mmHg | |
| Molecular Formula | C29H39N5O7 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 553.7±34.3 °C | |
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Agonist activation of p42 and p44 mitogen-activated protein kinases following expression of the mouse delta opioid receptor in Rat-1 fibroblasts: effects of receptor expression levels and comparisons with G-protein activation.
Biochem. J. 320 , 227-235, (1996) Rat-1 fibroblasts were transfected with a cDNA encoding the mouse delta opioid receptor. Two separate clones, D2 (which expressed some 6 pmol of the receptor/mg of membrane protein) and DOE (which expressed some 0.2 pmol/mg of membrane protein), were examined... |
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Activation of mu- and delta-opioid receptors causes presynaptic inhibition of glutamatergic excitation in neocortical neurons.
Anesthesiology 93 , 1053-1063, (2000) The mechanism underlying the depressant effect of opioids on neuronal activity within the neocortex is still not clear. Three modes of action have been suggested: (1) inhibition by activation of postsynaptic potassium channels, (2) interaction with postsynapt... |
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Direct excitatory opiate effects mediated by non-synaptic actions on rat medial vestibular neurons.
Eur. J. Pharmacol. 262 , 99-106, (1994) Opiates increase firing of rat medial vestibular nucleus neurons. We have attempted to determine the mechanism of these excitatory opiate actions by extracellular recording of neuronal activity with ionophoretic application of opiate agonists and bath applica... |
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Determination of enkephalin peptides by nonaqueous capillary electrophoresis with electrochemical detection.
Electrophoresis 27 , 1199-1208, (2006) Nonaqueous capillary electrophoresis with electrochemical detection (NACE-ED) was applied to the analysis of enkephalin peptides. The effect of different buffer compositions on the electrophoretic behavior of methionine enkephalin, leucine enkephalin, and [D-... |
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Leucine enkephalin effects on paracellular and transcellular permeation pathways across brain microvessel endothelial cell monolayers.
J. Cardiovasc. Pharmacol. 24 , 818-825, (1994) Leucine enkephalin (YGGFL) effects on markers for transcellular and paracellular permeation across the blood-brain barrier (BBB) were investigated in vitro with bovine brain microvessel endothelial cell (BMEC) monolayers in primary culture. Intact YGGFL, but ... |