Lactose
Names
[ CAS No. ]:
63-42-3
[ Name ]:
Lactose
[Synonym ]:
b-Lactose
β-Lactose
SUGAR MILK
EINECS 200-559-2
b-D-glucopyranose, 4-O-b-D-galactopyranosyl-
LACTOBIOSE
Aletobiose
D-LACTOSE
LACTIN
4-O-b-D-galactopyranosyl-b-D-glucopyranose
Lactose (8CI)
Lactose
4-O-β-D-Galactopyranosyl-β-D-glucopyranose
Osmolactan
Galactinum
β-D-Glucopyranose, 4-O-β-D-galactopyranosyl-
4-(b-D-Galactosido)-D-glucose
MFCD00151251
Biological Activity
[Description]:
[Related Catalog]:
[Target]
Human Endogenous Metabolite
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.8±0.1 g/cm3
[ Boiling Point ]:
667.9±55.0 °C at 760 mmHg
[ Melting Point ]:
222.8°C
[ Molecular Formula ]:
C12H22O11
[ Molecular Weight ]:
342.297
[ Flash Point ]:
357.8±31.5 °C
[ Exact Mass ]:
342.116211
[ PSA ]:
197.37000
[ LogP ]:
-3.41
[ Vapour Pressure ]:
0.0±4.6 mmHg at 25°C
[ Index of Refraction ]:
1.652
[ Stability ]:
Stable. Incompatible with strong oxidizing agents.
[ Water Solubility ]:
5-10 g/100 mL at 20 ºC
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OD9625000
- CHEMICAL NAME :
- Lactose
- CAS REGISTRY NUMBER :
- 63-42-3
- BEILSTEIN REFERENCE NO. :
- 0093796
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C12-H22-O11
- MOLECULAR WEIGHT :
- 342.34
- WISWESSER LINE NOTATION :
- T6OTJ BQ CQ DQ F1Q EO- BT6OTJ CQ DQ EQ F1Q -D
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 3,2427,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 3,2427,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 3,2427,1975
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 1500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4452 gm/kg/53W-C
- TOXIC EFFECTS :
- Gastrointestinal - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight
- REFERENCE :
- JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 11,165,1992
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 41 gm/kg/26W-C
- TOXIC EFFECTS :
- Cardiac - changes in heart weight Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count
- REFERENCE :
- JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 11,219,1992 ** TUMORIGENIC DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1000 gm/kg/29w-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
- REFERENCE :
- GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP. Volume(issue)/page/year: 46,363,1955 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 375 mg/kg
- SEX/DURATION :
- female 4-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 4,497,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81715 No. of Facilities: 3594 (estimated) No. of Industries: 19 No. of Occupations: 35 No. of Employees: 26586 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9297 No. of Facilities: 78 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1207 (estimated) No. of Female Employees: 922 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81715 No. of Facilities: 4424 (estimated) No. of Industries: 33 No. of Occupations: 51 No. of Employees: 132323 (estimated) No. of Female Employees: 76197 (estimated)
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xi
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
2
[ RTECS ]:
OD9625000
[ HS Code ]:
1702190000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 1702190000
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