24, 25-Dihydroxy VD2

Names

[ CAS No. ]:
58050-55-8

[ Name ]:
24, 25-Dihydroxy VD2

[Synonym ]:
(4E,6R)-2,3-Dimethyl-6-[(1R,3aS,4E,7aR)-octahydro-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]-7a-methyl-1H-inden-1-yl]-4-heptene-2,3-diol
24,25-Dihydroxy VD2
24,25-Dihydroxy Vitamin D2
(3|A,5Z,7E,22E,24|I)-9,10-Secoergosta-5,7,10(19),22-tetraene-3,24,25-triol
(24R)-24,25-dihydroxyvitamin D2
24(S),25-dihydroxyvitamin D2
CS-0802
24, 25-Dihydroxy VD2

Biological Activity

[Description]:

24, 25-Dihydroxy VD2 is a hydroxylated metabolite of Vitamin D2; a synthetic analog of Vitamin D.

[Related Catalog]:

Signaling Pathways >> Vitamin D Related >> VD/VDR

Research Areas >> Metabolic Disease

[References]

[1]. McGraw CA, Hug G. Simultaneous measurement of 25-hydroxy, 24,25-dihydroxy-, and 1,25-dihydroxyvitamin D without use of HPLC. Med Lab Sci. 1990 Jan;47(1):17-25.

[2]. Katsumi K, Okano T, Ono Y, Maegaki E, Nishimura K, Baba M, Kobayashi T, Miyata O, Naito T, Ninomiya I. Syntheses of 24,25-dihydroxyvitamin D2, 24,25-dihydroxy-22-dehydrovitamin D3, 25-hydroxy-24-oxo-22-dehydrovitamin D3 and 22,24,25-trihydroxyvitamin D3.

[3]. Horst RL, Littledike ET, Gray RW, Napoli JL. Impaired 24,25-dihydroxyvitamin D production in anephric human and pig. J Clin Invest. 1981 Jan;67(1):274-80.

[4]. Glenville Jones2, Heinrich K. Schnoes, Leon Levan et al.Isolation and identification of 24-hydroxyvitamin D2 and 24,25-dihydroxyvitamin D2. Archives of Biochemistry and Biophysics.Volume 202, Issue 2, July 1980, Pages 450-457

[5]. Glenville Jones, Alan Rosenthal,David Segev et al. Isolation and identification of 24,25-dihydroxy vitamin D2 by use of the perfused rat kidney. Biochemistry, 1979, 18 (6), pp 1094-1101

[Related Small Molecules]

Calcipotriene | Maxacalcitol | Paricalcitol | Vitamin D3 | 25-Hydroxycalciferol | 3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 | Secalciferol | Seocalcitol | 25,26-Dihydroxyvitamin D3 | Calcitetrol | Eldecalcitol | Ergocalciferol | Vitamin D4 | Calcipotriol Impurity C | MC 1046

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₄₄O₃

[ Molecular Weight ]:
428.64700

[ Exact Mass ]:
428.32900

[ PSA ]:
60.69000

[ LogP ]:
5.87080

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds