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MC 1046

Names

[ CAS No. ]:
126860-83-1

[ Name ]:
MC 1046

[Synonym ]:
2-Penten-1-one, 1-cyclopropyl-4-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(3S,5R)-3,5-dihydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-, (2E,4R)-
G70BS4HF9Z
MFCD00872035
MC-1046
(1S,3R,5Z,7E,22E)-1,3-Dihydroxy-26,27-cyclo-9,10-secocholesta-5,7,10,22-tetraen-24-one

Biological Activity

[Description]:

MC 1046(Impurity A of Calcipotriol) is an impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors. IC50 value:Target: Vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; Calcipotriol (MC 903; Calcipotriene) exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.

[Related Catalog]:

Signaling Pathways >> Vitamin D Related >> VD/VDR
Research Areas >> Cancer

[References]

[1]. Binderup (1993) Comparison of calcipotriol with selected metabolites and analogues of vitamin D3: effects on cell growth regulation in vitro and calcium metabolism in vivo. Pharmacol.Toxicol. 72 240.

[2]. Knutson et al (1997) Pharmacokinetics and systemic effect on calcium homeostasis of 1a,24-dihydroxyvitamin D2 in rats. Biochem.Pharmacol. 53 829.

[3]. Wietrzyk et al (2007) Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anticancer Drugs 18 447.111

[4]. P.J. Marie, D. Connes, M. Hott, L. Miravet. Comparative effects of a novel Vitamin D Analogue MC-903 and 1,25-dihydroxyvitamin D3 on alkaline phosphatase activity, osteocalcin and DNA synthesis by human osteoblastic cells in culture. Bone. Volume 11, Issue 3, 1990, Pages 171-179


[Related Small Molecules]

Calcipotriene | Maxacalcitol | Paricalcitol | Vitamin D3 | 25-Hydroxycalciferol | 3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 | Secalciferol | Seocalcitol | 25,26-Dihydroxyvitamin D3 | Calcitetrol | Eldecalcitol | Ergocalciferol | Vitamin D4 | 24, 25-Dihydroxy VD2 | Calcipotriol Impurity C

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
584.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C27H38O3

[ Molecular Weight ]:
410.589

[ Flash Point ]:
321.1±26.6 °C

[ Exact Mass ]:
410.282104

[ LogP ]:
4.95

[ Vapour Pressure ]:
0.0±3.7 mmHg at 25°C

[ Index of Refraction ]:
1.574

[ Storage condition ]:
2-8℃

Related Compounds