25-Hydroxycalciferol

Names

[ Name ]:
25-Hydroxycalciferol

[Synonym ]:
25-Hydroxy Vitamin D2
(3S,5Z,7E,20R,22E)-9,10-Secoergosta-5,7,10,22-tetraene-3,25-diol
9,10-Secoergosta-5,7,10(19),22-tetraene-3b,25-diol
9,10-Secoergosta-5,7,10(19),22-tetraene-3β,25-diol
Ercalcidiol,3β,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3,25-diol
EINECS 200-578-6
25-Hydroxyvitamin D2
25-Hydroxyvitamin D 2
25-Hydroxyergocalciferol
25-Hydroxyergocalciferol 25-Hydroxycalciferol
Cyclohexanol, 4-methylene-3-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-trimethyl-2-hexen-1-yl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1S,3Z)-
9,10-Secoergosta-5,7,10(19),22-tetraene-3,25-diol, (3β,5Z,7E,22E)-
MFCD02683431
25-Hydroxycalciferol
Ercalcidiol

Biological Activity

[Description]:

Ercalcidiol is a metabolite of vitamin D2, is regarded as an indicator of vitamin D nutritional status.

[Related Catalog]:

Signaling Pathways >> Vitamin D Related >> VD/VDR

Research Areas >> Metabolic Disease

Natural Products >> Steroids

[Target]

Human Endogenous Metabolite

[In Vitro]

Differentiation between Ercalcidiol (25(OH)D2) and 25(OH)D3 is important for monitoring vitamin D therapy, as vitamin D2 is the predominant prescription form. The half-life of Ercalcidiol is shorter than that of 25(OH)D3 and it binds less well to the vitamin D binding protein, making it less potent and, therefore, required to be administered at much higher doses than vitamin D3. Some currently used assays have a diminished capacity to detect Ercalcidiol, which can lead to dangerous overdosing when attempting to monitor therapy with vitamin D2[2].

[References]

[1]. Li L, et al. Performance evaluation of two immunoassays for 25-hydroxyvitamin D. J Clin Biochem Nutr. 2016 May;58(3):186-92.

[2]. Newman MS, et al. A liquid chromatography/tandem mass spectrometry method for determination of 25-hydroxy vitamin D2 and 25-hydroxy vitamin D3 in dried blood spots: a potential adjunct to diabetes and cardiometabolic risk screening. J Diabetes Sci Technol

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
542.3±38.0 °C at 760 mmHg

[ Melting Point ]:
45-51ºC

[ Molecular Formula ]:
C₂₈H₄₄O₂

[ Molecular Weight ]:
412.648

[ Flash Point ]:
225.9±21.4 °C

[ Exact Mass ]:
412.334137

[ PSA ]:
40.46000

[ LogP ]:
7.56

[ Vapour Pressure ]:
0.0±3.3 mmHg at 25°C

[ Index of Refraction ]:
1.543

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H319

[ Precautionary Statements ]:
P210-P280-P305 + P351 + P338-P337 + P313-P403 + P235

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T+,F

[ Risk Phrases ]:
24/25-26-48/25-11

[ Safety Phrases ]:
28-36/37-45-16-7

[ RIDADR ]:
UN2811 6

Precursor & DownStream

Precursor

DownStream

Articles

Improved analysis of vitamin D metabolites in plasma using liquid chromatography tandem mass spectrometry, and its application to cardiovascular research.

Biomed. Chromatogr. 28(6) , 913-7, (2014)

The accurate and specific measurement of vitamin D is increasingly important for determining the role of vitamin D in the pathogenesis of disease. Liquid chromatography coupled to tandem mass spectrom...

Common variants in CYP2R1 and GC genes are both determinants of serum 25-hydroxyvitamin D concentrations after UVB irradiation and after consumption of vitamin D₃-fortified bread and milk during winter in Denmark.

Am. J. Clin. Nutr. 101(1) , 218-27, (2015)

Little is known about how the genetic variation in vitamin D modulating genes influences ultraviolet (UV)B-induced 25-hydroxyvitamin D [25(OH)D] concentrations. In the Food with vitamin D (VitmaD) stu...

Prospective association of 25-hydroxyvitamin d3 and d2 with childhood lung function, asthma, wheezing, and flexural dermatitis.

Epidemiology 24(2) , 310-9, (2013)

Higher serum total 25-hydroxyvitamin D (25(OH)D) concentrations have been associated with better lung function and lower risk of allergic disease. 25(OH)D3 constitutes the majority of total 25(OH)D an...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.