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24 25-Dihydroxy VD3

Names

[ CAS No. ]:
40013-87-4

[ Name ]:
24 25-Dihydroxy VD3

[Synonym ]:
24R,25-dihydroxycholecalciferol
24,25 dihydroxycholecalciferol
24,25-dihydroxyvitamin D3
24,25-dihydroxycholecalciferol
24,25-dihydroxy-vitamin D3
(R)-6-{(1R,3aS,7aR)-4-[2-[(S)-5-Hydroxy-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-2-methyl-heptane-2,3-diol
24, 25-Dihydroxy VD3

Biological Activity

[Description]:

24, 25-Dihydroxy VD3 is a compound which is closely related to 1,25-dihydroxyvitamin D3, the active form of vitamin D3, but like vitamin D3 itself and 25-hydroxyvitamin D3 is inactive as a hormone both in vitro and in vivo.

[Related Catalog]:

Signaling Pathways >> Vitamin D Related >> VD/VDR
Research Areas >> Metabolic Disease
Natural Products >> Others

[Target]

Human Endogenous Metabolite


[References]

[1]. Takayama H.Creation of functional organic compounds and their applicationsYakugaku Zasshi. 2002 Feb;122(2):127-55.

[2]. Kim YR, Abraham NG, Lutton JD.Mechanisms of differentiation of U937 leukemic cells induced by GM-CSF and 1,25(OH)2 vitamin D3.Leuk Res. 1991;15(6):409-18.

[3]. Dennis Wagner, Heather E. Hanwell, Kareena Schnabl et al. The ratio of serum 24,25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 is predictive of 25-hydroxyvitamin D3 response to vitamin D3 supplementation. The Journal of Steroid Biochemistry and Molecular Biology.Volume 126, Issues 3-5, September 2011, Pages 72-77


[Related Small Molecules]

3-Methyladenine | Hydrocortisone | Acetylcysteine(N-acetylcysteine) | Retinoic acid | Melatonine | Dinoprostone | Nicotinamide | Adenosine triphosphate | 4-Acetamidophenol | Prostaglandin E1 | Dehydroepiandrosterone | Calcipotriene | Corticosterone | Progesterone | Docosahexaenoic Acid

Chemical & Physical Properties

[ Molecular Formula ]:
C27H44O3

[ Molecular Weight ]:
416.63600

[ Exact Mass ]:
416.32900

[ PSA ]:
60.69000

[ LogP ]:
5.70470

[ Storage condition ]:
2-8℃

Related Compounds