Salsolidine

Names

[ Name ]:
Salsolidine

[Synonym ]:
rac-salsolidine
6,7-DIMETHOXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE
1,2,3,4-tetrahydro-6,7-dimethoxy-1-methylisoquinoline
1-methyl-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline
Salsolidine

Biological Activity

[Description]:

Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

Natural Products >> Alkaloid

Research Areas >> Neurological Disease

[Target]

MAO A[1]

[In Vitro]

Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor. The R-salsolidine is more active against MAO A than S-salsolidine (Ki, 6 μM and 186 μM)[1]. Salsolidine weakly inhibits the binding of δ-receptor, with a Ki of >100 μM[2]. Salsolidine has the potential of inhibiting Acetylcholinestearse and butyrylcholinesterase[3].

[References]

[1]. Bembenek ME, et al. Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optically active 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolines. J Med Chem. 1990 Jan;33(1):147-52.

[2]. Airaksinen MM, et al. Binding of beta-carbolines and tetrahydroisoquinolines by opiate receptors of the delta-type. Acta Pharmacol Toxicol (Copenh). 1984 Nov;55(5):380-5.

[3]. Tundis R, et al. A potential role of alkaloid extracts from Salsola species (Chenopodiaceae) in the treatment of Alzheimer's disease. J Enzyme Inhib Med Chem. 2009 Jun;24(3):818-24.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.034g/cm3

[ Boiling Point ]:
313.4ºC at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₇NO₂

[ Molecular Weight ]:
207.26900

[ Flash Point ]:
127.1ºC

[ Exact Mass ]:
207.12600

[ PSA ]:
30.49000

[ LogP ]:
2.23930

[ Storage condition ]:
2-8℃

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2933499090

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%