(S)-Salsolidine

Names

[ CAS No. ]:
493-48-1

[ Name ]:
(S)-Salsolidine

[Synonym ]:
rac-salsolidine
6,7-DIMETHOXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE
1,2,3,4-tetrahydro-6,7-dimethoxy-1-methylisoquinoline
1-methyl-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline

Biological Activity

[Description]:

(S)-Salsolidine is a weak monoamine oxidase (MAO) inhibitor (Ki=63 μM). The R enantiomer of Salsolidine is more potent than the S form (Ki=26 μM)[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

Research Areas >> Neurological Disease

[Target]

Human Endogenous Metabolite

[In Vitro]

Salsolidine is a dopamine-derived tetrahydroisoquinoline-alkaloid which possesses an asymmetric center at C-1 and exists as R and S enantiomers[1].

[References]

[1]. Dostert P, et al. Dopamine-derived alkaloids in alcoholism and in Parkinson's and Huntington's diseases. J Neural Transm. 1988;74(2):61-74.

Chemical & Physical Properties

[ Density]:
1.034g/cm3

[ Boiling Point ]:
313.4ºC at 760mmHg

[ Molecular Formula ]:
C₁₂H₁₇NO₂

[ Molecular Weight ]:
207.27

[ Flash Point ]:
127.1ºC

[ Exact Mass ]:
207.12600

[ PSA ]:
30.49000

[ LogP ]:
2.23930

[ Vapour Pressure ]:
0.000496mmHg at 25°C

[ Index of Refraction ]:
1.509

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NX5018500

CHEMICAL NAME :: Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-methyl-

CAS REGISTRY NUMBER :: 493-48-1

LAST UPDATED :: 199312

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H17-N-O2

MOLECULAR WEIGHT :: 207.30

WISWESSER LINE NOTATION :: T66 CMT&J B1 HO1 IO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 41,249,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 170 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 15(2),54,1981

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.