Palmitic acid

Names

[ CAS No. ]:
57-10-3

[ Name ]:
Palmitic acid

[Synonym ]:
n-hexadecanoic acid
1-hexadecanoic acid
hexdecanoic acid
Hexadecanoic acid
MFCD00002747
EINECS 200-312-9
Neo-Fat 16
Palmitic acid

Biological Activity

[Description]:

Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants.

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Research Areas >> Metabolic Disease

Research Areas >> Neurological Disease

Natural Products >> Others

[Target]

Human Endogenous Metabolite

[References]

[1]. Harada H, et al. Antitumor activity of palmitic acid found as a selective cytotoxic substance in a marine red alga. Anticancer Res. 2002 Sep-Oct;22(5):2587-90.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
340.6±5.0 °C at 760 mmHg

[ Melting Point ]:
61-62.5 °C(lit.)

[ Molecular Formula ]:
C₁₆H₃₂O₂

[ Molecular Weight ]:
256.424

[ Flash Point ]:
154.1±12.5 °C

[ Exact Mass ]:
256.240234

[ PSA ]:
37.30000

[ LogP ]:
7.15

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.454

[ Stability ]:
Stable. Combustible. Incompatible with bases, oxidizing agents, reducing agents.

[ Water Solubility ]:
insoluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RT4550000

CHEMICAL NAME :: Palmitic acid

CAS REGISTRY NUMBER :: 57-10-3

BEILSTEIN REFERENCE NO. :: 0607489

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C16-H32-O2

MOLECULAR WEIGHT :: 256.48

WISWESSER LINE NOTATION :: QV15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

REFERENCE :: 85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 Volume(issue)/page/year: -,127,1977 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 37,251,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 57 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 18,141,1961 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1000 mg/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 26,105,1966 *** REVIEWS *** TOXICOLOGY REVIEW AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 21,100,1960 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81460 No. of Facilities: 1477 (estimated) No. of Industries: 23 No. of Occupations: 34 No. of Employees: 20670 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81460 No. of Facilities: 5543 (estimated) No. of Industries: 55 No. of Occupations: 61 No. of Employees: 105420 (estimated) No. of Female Employees: 20470 (estimated)

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
-

[ RTECS ]:
RT4550000

[ HS Code ]:
2915709000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2915709000

[ Summary ]:
2915709000. palmitic acid and its salts and esters. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Kinetics and utilization of lipid sources during acute exercise and acipimox.

Am. J. Physiol. Endocrinol. Metab. 307(2) , E199-208, (2014)

Overweight is associated with abnormalities of lipid metabolism, many of which are reversed by exercise. We investigated the impact of experimental antilipolysis and acute exercise on lipid kinetics a...

Hepatitis C virus entry is impaired by claudin-1 downregulation in diacylglycerol acyltransferase-1-deficient cells.

J. Virol. 88(16) , 9233-44, (2014)

Diacylglycerol acyltransferase-1 (DGAT1) is involved in the assembly of hepatitis C virus (HCV) by facilitating the trafficking of the HCV core protein to the lipid droplet. Here, we abrogated DGAT1 e...

The nuclear receptor DAF-12 regulates nutrient metabolism and reproductive growth in nematodes.

PLoS Genet. 11(3) , e1005027, (2015)

Appropriate nutrient response is essential for growth and reproduction. Under favorable nutrient conditions, the C. elegans nuclear receptor DAF-12 is activated by dafachronic acids, hormones that com...