Scutellarein

Names

[ CAS No. ]:
529-53-3

[ Name ]:
Scutellarein

[Synonym ]:
4H-1-Benzopyran-4-one, 5,6,7-trihydroxy-2-(4-hydroxyphenyl)-
5,6,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
5,6,7,4'-tetrahydroxyflavone
5,6,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
4',5,6,7-Tetrahydroxyflavanone
6-Hydroxypelargidenon 1465
Scutellarein

Biological Activity

[Description]:

Scutellarin, a main active ingredient extracted from Erigeron breviscapus (Vant.) Hand-Mazz., has been wildly used to treat acute cerebral infarction and paralysis induced by cerebrovascular diseases.

[Related Catalog]:

Signaling Pathways >> Autophagy >> Autophagy

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src

Research Areas >> Inflammation/Immunology

Natural Products >> Flavonoids

[References]

[1]. Xiaoxuan Tian, et al. Delineation of Platelet Activation Pathway of Scutellarein Revealed Its Intracellular Target as Protein Kinase C. Biological and Pharmaceutical BulletinVol. 39 (2016) No. 2 p. 181-191

[2]. Sung NY, et al. Scutellarein Reduces Inflammatory Responses by Inhibiting Src Kinase Activity. Korean J Physiol Pharmacol. 2015 Sep;19(5):441-9.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
642.9±55.0 °C at 760 mmHg

[ Melting Point ]:
330ºC

[ Molecular Formula ]:
C₁₅H₁₀O₆

[ Molecular Weight ]:
286.236

[ Flash Point ]:
249.9±25.0 °C

[ Exact Mass ]:
286.047729

[ PSA ]:
111.13000

[ LogP ]:
2.54

[ Appearance of Characters ]:
yellow

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.768

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: soluble1mg/mL, clear, greenish-yellow

MSDS

Click to get detail MSDS

Safety Information

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2914501900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914501900

[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

Delineation of Platelet Activation Pathway of Scutellarein Revealed Its Intracellular Target as Protein Kinase C.

Biol. Pharm. Bull. 39 , 181-91, (2016)

Erigeron breviscapus has been widely used in traditional Chinese medicine (TCM) and its total flavonoid component is commonly used to treat ischemic stroke, coronary heart disease, diabetes and hypert...

Liquid Chromatography-Tandem Mass Spectrometry Screening Method for the Detection of Radical-Scavenging Natural Antioxidants from the Whole Scutellariae (Radix, Stem and Leaf).

J. Chromatogr. Sci. 53 , 1140-6, (2015)

A novel free radical reaction combined with high-performance LC-photodiode array-ESI-MS/MS screening method was developed for the detection and identification of natural antioxidants from whole Scutel...

Effect of light, methyl jasmonate and cyclodextrin on production of polyphenolic compounds in hairy root cultures of Scutellaria lateriflora

Phytochemistry 107 , 50-60, (2014)

Graphical abstract [Display omitted]

Related Compounds

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