Ladanetin

Names

[ Name ]:
Ladanetin

[Synonym ]:
7-O-methyl-seutellarin
5,6,4'-trihydroxy-7-methoxyflavone
7-methoxy-4',5,6-trihydroxyflavone
5,6-dihydroxy-7,4'-dimethoxyflavone
7-methylscutellarein
Sorbifolin
7-O-methyl-seutellarein
Ladanetin

Biological Activity

[Description]:

Sorbifolin, a flavone glucoside, can be isolated from the Pterogyne nitens. Sorbifolin has myeloperoxidase inhibitory and radical scavenging activities. Sorbifolin is also a MPO inhibitor with an IC50 value of 19.2 nM[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[Target]

IC50: 19.2 nM (Myeloperoxidase, MPO)[1].

[In Vitro]

Sorbifolin (30 min) 显示出自由基清除活性，清除 ABTS 自由基和 DPPH 自由基的 IC50 分别为 5.7 μM 和 13.5 μM[1]。

[References]

[1]. Fernandes DC, et al. Myeloperoxidase inhibitory and radical scavenging activities of flavones from Pterogyne nitens. Chem Pharm Bull (Tokyo). 2008 May;56(5):723-6.

Chemical & Physical Properties

[ Density]:
1.512g/cm3

[ Boiling Point ]:
601.7ºC at 760mmHg

[ Molecular Formula ]:
C₁₆H₁₂O₆

[ Molecular Weight ]:
300.26300

[ Flash Point ]:
230.2ºC

[ Exact Mass ]:
300.06300

[ PSA ]:
100.13000

[ LogP ]:
2.58540

[ Vapour Pressure ]:
4.5E-15mmHg at 25°C

[ Index of Refraction ]:
1.697

Safety Information

[ HS Code ]:
2914509090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%