Scutellarein
Scutellarein structure
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Common Name | Scutellarein | ||
|---|---|---|---|---|
| CAS Number | 529-53-3 | Molecular Weight | 286.236 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 642.9±55.0 °C at 760 mmHg | |
| Molecular Formula | C15H10O6 | Melting Point | 330ºC | |
| MSDS | Chinese USA | Flash Point | 249.9±25.0 °C | |
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Delineation of Platelet Activation Pathway of Scutellarein Revealed Its Intracellular Target as Protein Kinase C.
Biol. Pharm. Bull. 39 , 181-91, (2016) Erigeron breviscapus has been widely used in traditional Chinese medicine (TCM) and its total flavonoid component is commonly used to treat ischemic stroke, coronary heart disease, diabetes and hypertension. Scutellarin is the major ingredient of E. breviscap... |
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Liquid Chromatography-Tandem Mass Spectrometry Screening Method for the Detection of Radical-Scavenging Natural Antioxidants from the Whole Scutellariae (Radix, Stem and Leaf).
J. Chromatogr. Sci. 53 , 1140-6, (2015) A novel free radical reaction combined with high-performance LC-photodiode array-ESI-MS/MS screening method was developed for the detection and identification of natural antioxidants from whole Scutellariae. Six compounds and whole Scutellariae extracts were ... |
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Effect of light, methyl jasmonate and cyclodextrin on production of polyphenolic compounds in hairy root cultures of Scutellaria lateriflora
Phytochemistry 107 , 50-60, (2014) Graphical abstract [Display omitted] |
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Bioactive diterpenoids and flavonoids from the aerial parts of Scoparia dulcis.
J. Nat. Prod. 77(7) , 1594-600, (2014) Six new diterpenoids, 4-epi-7α-O-acetylscoparic acid A (1), 7α-hydroxyscopadiol (2), 7α-O-acetyl-8,17β-epoxyscoparic acid A (3), neo-dulcinol (4), dulcinodal-13-one (5), and 4-epi-7α-hydroxydulcinodal-13-one (6), and a new flavonoid, dillenetin 3-O-(6″-O-p-co... |
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Anti-influenza virus activity of the ethanolic extract from Peperomia sui.
J. Ethnopharmacol. 155(1) , 320-5, (2014) Peperomia sui Lin and Lu (Peperomia sui), a well-known Taiwanese folk medicine, has a broad range of biological effects, especially in treatment of upper respiratory tract diseases. However, no previous study has explored the activity of Peperomia sui against... |
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Development of chemical inhibitors of the SARS coronavirus: viral helicase as a potential target.
Biochem. Pharmacol. 84(10) , 1351-8, (2012) Severe acute respiratory syndrome (SARS) was the first pandemic in the 21st century to claim more than 700 lives worldwide. However, effective anti-SARS vaccines or medications are currently unavailable despite being desperately needed to adequately prepare f... |
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Flavone derivatives as inhibitors of insulin amyloid-like fibril formation.
PLoS ONE 10(3) , e0121231, (2015) Several natural and synthetic flavone derivatives have been reported to inhibit formation of amyloid fibrils or to remodel existing fibrils. These studies suggest that the numbers and positions of hydroxyl groups on the flavone rings determine their effective... |
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[Advances in studies on pharmacokinetics of scutellarin and scutellarein].
Zhongguo Zhong Yao Za Zhi 34(24) , 3165-8, (2009) Scutellarin is the major effective ingredient of breviscapine, which is widely used in the treatment of cardiovascular diseases and has a remarkable achievement. In recent years, more and more reseaches had focused on the pharmacokinetics of scutellarin and s... |
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Design, synthesis and biological evaluation of glucose-containing scutellarein derivatives as neuroprotective agents based on metabolic mechanism of scutellarin in vivo.
Bioorg. Med. Chem. Lett. 23(1) , 102-6, (2013) Based on metabolic mechanism of scutellarin in vivo that scutellarin could be hydrolyzed into scutellarein by β-glucuronide enzyme, some glucose-containing scutellarein derivatives were designed and synthesized through the introduction of glucose moiety at C-... |
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Synthesis and protective effect of scutellarein on focal cerebral ischemia/reperfusion in rats.
Molecules 17(9) , 10667-74, (2012) Scutellarein, the main metabolite of scutellarin in vivo, has relatively better solubility, bioavailability and bio-activity than scutellarin. However, compared with scutellarin, it is very difficult to obtain scutellarein from Nature. Therefore, the present ... |