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Substance P (7-11)

Names

[ CAS No. ]:
51165-05-0

[ Name ]:
Substance P (7-11)

[Synonym ]:
Substance P (7-11)
Penta-Substance P
Phe-Phe-Gly-Leu-Met-NH2
SUBSTANCE P,Fragment 7-11
2-{2-[2-(2-amino-3-phenylpropanamido)-3-phenylpropanamido]acetamido}-N-[1-carbamoyl-3-(methylsulfanyl)propyl]-4-methylpentanamide
H-Phe-Phe-Gly-Leu-Met-NH2

Biological Activity

[Description]:

Substance P (7-11) is a C-terminal fragment of Substance P which can cause an increase in the intracellular calcium concentration.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor
Research Areas >> Neurological Disease
Peptides

[In Vitro]

Substance P (7-11) increases PGE2 and collagenase production at concentrations greater than 1 μM. Substance P (7-11), but not intact SP, SP-(1-4), SP-(1-6), SP- (8-11) or SP-(9-1 1), nor the tachykinins NKA and NKB, causes an increase in the intracellular calcium concentration as measured by the fluorescent dye Fura-2. The maximal change in intracellular calcium induced by 10 μM Substance P (7-11) was 140±30 nM[1].

[Cell Assay]

Confluent chondrocytes are incubated for 24 h with SP or Substance P (7-11). TIMP activity is inactivated following reduction and alkylation with 2 mM dithiothreitol and 5 mM iodoacetamide for 30 min at 37°C. Samples are subsequently dialysed. Latent collagenase is activated with 1 mM APt followed by inactivation with soy bean trypsin inhibitor. Collagenase is measured[1].

[References]

[1]. Halliday DA, et al. The substance P fragment SP-(7-11) increases prostaglandin E2, intracellular Ca2+ and collagenase production in bovine articular chondrocytes. Biochem J. 1993 May 15;292 ( Pt 1):57-62.


[Related Small Molecules]

Substance P acetate salt | rolapitant | SB-222200 | Fezolinetant | Netupitant | [Sar9,Met(O2)11]-Substance P TFA | MLE-4901 | Succinyl-(Asp6,N-Me-Phe8)-Substance P (6-11) | Maropitant | NKP608 | Serlopitant | Talnetant | Y1 receptor antagonist 1 | [bAla8]-Neurokinin A(4-10)

Chemical & Physical Properties

[ Density]:
1.207g/cm3

[ Boiling Point ]:
1003.3ºC at 760 mmHg

[ Molecular Formula ]:
C31H44N6O5S

[ Molecular Weight ]:
612.78300

[ Flash Point ]:
560.6ºC

[ Exact Mass ]:
612.30900

[ PSA ]:
210.81000

[ LogP ]:
3.61840

[ Index of Refraction ]:
1.577

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds