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PYR-PHE-PHE-GLY-LEU-MET-NH2

Names

[ CAS No. ]:
61123-13-5

[ Name ]:
PYR-PHE-PHE-GLY-LEU-MET-NH2

[Synonym ]:
[PYR1]-SUBSTANCE P (6-11)
Substance P,fragment 6-11,[pGlu6]
pGln-Phe-Phe-Gly-Leu-Met-NH2
PGLU-PHE-PHE-GLY-LEU-MET-NH2
substance P (6-11),pGlu(6)
(PYR6)-SUBSTANCE P (6-11)
SUBSTANCE P [PGLU6]-FRAGMENT 6-11
PYR-PHE-PHE-GLY-LEU-MET-NH2
GLP-PHE-PHE-GLY-LEU-MET-NH2
pyroglutamyl-phenylalanyl-phenylalanine-glycyl-leucyl-methionine amide
[GLP6] SUBSTANCE P (6-11)
(p-Glu6)SP6-11
pglu6-substance P fragment 6-11
[pGlu(6)]-substance P(6-11)

Biological Activity

[Description]:

[Glp6] Substance P (6-11) is an analogue of substance P (6-11). Substance P (6-11) stimulates [3H]-inositol monophosphate ([3H]-IP1) formation in rat urinary bladder by acting on the 'septide-sensitive' tachykinin receptors[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[References]

[1]. Brzezinski P M, Godlewski A. The effect of caltitonin, somatostain and analogue (Glp6) of substance P (6-11) on chemotaxis and phagocytosis of guinea pig heterophilis in vitro. Folia Histochemica et Cytobiologica, 1991, 29(4).

[2]. Torrens Y, et al. Substance P(6-11) and natural tachykinins interact with septide-sensitive tachykinin receptors coupled to a phospholipase C in the rat urinary bladder. Neuropeptides. 1997 Jun;31(3):243-51.  

Chemical & Physical Properties

[ Density]:
1.247g/cm3

[ Boiling Point ]:
1195.9ºC at 760 mmHg

[ Molecular Formula ]:
C36H49N7O7S

[ Molecular Weight ]:
723.88200

[ Flash Point ]:
677ºC

[ Exact Mass ]:
723.34100

[ PSA ]:
242.99000

[ LogP ]:
3.07390

[ Index of Refraction ]:
1.579

MSDS

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Synthetic Route

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Related Compounds