Hemokinin 1 (human) trifluoroacetate salt

Names

[ Name ]:
Hemokinin 1 (human) trifluoroacetate salt

[Synonym ]:
h-thr-gly-lys-ala-ser-gln-phe-phe-gly-leu-met-nh2
thr-gly-lys-ala-ser-gln-phe-phe-gly-leu-met-nh2
hhk-1

Biological Activity

[Description]:

Hemokinin 1, human is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human can produces an opioid-independent analgesia[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[References]

[1]. Cai-Yun Fu, et al. Hemokinin-1(4-11)-induced analgesia selectively up-regulates δ-opioid receptor expression in mice. PLoS One

[2]. Francesca Bellucci, et al. Pharmacological profile of the novel mammalian tachykinin, hemokinin 1. Br J Pharmacol. 2002 Jan;135(1):266-74.

Chemical & Physical Properties

[ Density]:
1.282 g/cm3

[ Boiling Point ]:
1669.168ºC at 760 mmHg

[ Molecular Formula ]:
C₅₄H₈₄N₁₄O₁₄S

[ Molecular Weight ]:
1184.39000

[ Flash Point ]:
963.278ºC

[ Exact Mass ]:
1183.59000

[ PSA ]:
480.99000

[ LogP ]:
1.08700

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Centrally administered hemokinin-1 (HK-1), a neurokinin NK1 receptor agonist, produces substance P-like behavioral effects in mice and gerbils.

Neuropharmacology 45(2) , 242-50, (2003)

Hemokinin-1 (HK-1) is a recently described mouse tachykinin peptide whose biological functions are not fully understood. To date, a unique receptor for HK-1 has not been identified. Recent studies sug...

T-cell developmental blockage by tachykinin antagonists and the role of hemokinin 1 in T lymphopoiesis.

Blood 102(6) , 2165-72, (2003)

Hemokinin 1 (HK-1) is a new member of the tachykinin peptide family that is expressed in hematopoietic cells. Recent reports studying mouse, rat, and human orthologs of HK-1 demonstrate a broader dist...

Characterization of the endokinins: human tachykinins with cardiovascular activity.

Proc. Natl. Acad. Sci. U. S. A. 100 , 6245-6250, (2003)

We report four human tachykinins, endokinins A, B, C, and D (EKA-D), encoded from a single tachykinin precursor 4 gene that generates four mRNAs (alpha, beta, gamma, and delta). Tachykinin 4 gene expr...