Hippuric acid

Names

[ CAS No. ]:
495-69-2

[ Name ]:
Hippuric acid

[Synonym ]:
2-benzamidoacetic acid
BZ-GLY-OH
EINECS 207-806-3
Benzoylaminoacetic acid
Hippuric acid
(benzoylamino)-Acetic acid
Benzoylglycin
(Z)-N-[hydroxy(phenyl)methylidene]glycine
hippuric
N-(benzoyl)glycine
MFCD00002692
N-Benzoylglycine
Glycine, N-benzoyl-
Benzoylglycine
[3H]-Hippuric Acid
BZO-GLY-OH
acidoippurico
N-benzoylaminoacetic acid

Biological Activity

[Description]:

Hippuric Acid, an acyl glycine produced by the conjugation of benzoic acid and glycine, is a normal component in urine as a metabolite of aromatic compounds from food.

[Related Catalog]:

Natural Products >> Acids and Aldehydes

Research Areas >> Metabolic Disease

[Target]

Human Endogenous Metabolite

[References]

[1]. Niwa T, et al. Organic acids and the uremic syndrome: protein metabolite hypothesis in the progression of chronic renal failure. Semin Nephrol. 1996 May;16(3):167-82.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
464.1±28.0 °C at 760 mmHg

[ Melting Point ]:
187-191 °C(lit.)

[ Molecular Formula ]:
C₉H₉NO₃

[ Molecular Weight ]:
179.173

[ Flash Point ]:
234.5±24.0 °C

[ Exact Mass ]:
179.058243

[ PSA ]:
66.40000

[ LogP ]:
0.31

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.568

[ Storage condition ]:
Store at RT.

[ Stability ]:
Stable. Incompatible with oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MR8150000

CHEMICAL NAME :: Hippuric acid

CAS REGISTRY NUMBER :: 495-69-2

BEILSTEIN REFERENCE NO. :: 1073987

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H9-N-O3

MOLECULAR WEIGHT :: 179.19

WISWESSER LINE NOTATION :: QV1MVR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 112,53,1973

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn,Xi

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S26-S39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
MR8150000

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Urinary metabolic fingerprinting of mice with diet-induced metabolic derangements by parallel dual secondary column-dual detection two-dimensional comprehensive gas chromatography.

J. Chromatogr. A. 1361 , 265-76, (2014)

This study investigates the potential of a parallel dual secondary column-dual detection two-dimensional comprehensive GC platform (GC×2GC-MS/FID) for metabolic profiling and fingerprinting of mouse u...

Alteration of Gene Expression Profile in Kidney of Spontaneously Hypertensive Rats Treated with Protein Hydrolysate of Blue Mussel (Mytilus edulis) by DNA Microarray Analysis.

PLoS ONE 10(10) , e0142016, (2015)

Marine organisms are rich sources of bioactive components, which are often reported to have antihypertensive effects. However, the underlying mechanisms have yet to be fully identified. The aim of thi...

Development of a multi-residue method in a fetal matrix: analysis of meconium.

Anal. Bioanal. Chem 406(30) , 7785-97, (2014)

Meconium is the earliest stool of newborns. It is a complex matrix that reflects the degree of fetal exposure to environmental pollutants. To investigate exposure to xenobiotics, an analytical method ...

Related Compounds

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