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Ligustilide

Names

[ CAS No. ]:
4431-01-0

[ Name ]:
Ligustilide

[Synonym ]:
3-BUTYLIDENE-4,5-DIHYDROPHTHALIDE
3-BUTYLIDEN-4,5-DIHYDRO-3H-ISOBENZOFURAN-1-ONE
Ligustilide
3-Butyliden-1-oxo-1.3.4.5-tetrahydro-isobenzofuran
Angelica Extract Powder
LIGUSTILIDE,Z
cis-ligustilide
Ligustilide, (Z)-
1(3H)-Isobenzofuranone, 3-butylidene-4,5-dihydro-, (3Z)-
Z-LIGUSTILIDE
(3Z)-3-Butylidene-4,5-dihydro-2-benzofuran-1(3H)-one
3-butylidene-4,5-dihydro-3H-isobenzofuran-1-one

Biological Activity

[Description]:

Ligustilide is an effective constituent extracted from Angelica sinensis.IC50 value:Target:In vitro: To investigate the neuroprotective of ligustilide (LIG) against glutamate-induced apoptosis of PC12 cells, cell viability were examined by MTT assay. Pretreatment with ligustilide (1, 5, 15 μmol · L(-1)) significantly improved cell viability. The apoptosis rate in glutamate-induced PC12 cells was 13.39%, and decreased in the presence of ligustilide (1, 5, 15 μmol · L(-1)) by 9.06%, 6.48%, 3.82%, separately. Extracellular accumulation of Ca2+ induced by glutamate were significantly reduced by ligustilide [1].In vivo:

[Related Catalog]:

Signaling Pathways >> Autophagy >> Autophagy
Research Areas >> Others
Natural Products >> Others

[References]

[1]. Wu Q, et al. Protective effect of ligustilide against glutamate-induced apoptosis in PC12 cells. Yao Xue Xue Bao. 2015 Feb;50(2):162-8.

[2]. Du H, et al. A cell membrane chromatography method for investigation of 5-hydroxytryptamine receptor-ligustilide interaction. Se Pu. 2015 May;33(5):530-4.


[Related Small Molecules]

Rapamycin (Sirolimus) | MG-132 | Cycloheximide | 3-Methyladenine | LY294002 | TAK-242 | (+)-JQ1 | SB203580 | Pyrazolanthrone (SP600125) | U0126-EtOH | Actinomycin D | Chloroquine diphosphate | CHIR-99021 (CT99021) | MK-2206 2HCl | Dorsomorphin dihydrochloride

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
377.9±11.0 °C at 760 mmHg

[ Melting Point ]:
297-298ºC

[ Molecular Formula ]:
C12H14O2

[ Molecular Weight ]:
190.238

[ Flash Point ]:
158.6±16.7 °C

[ Exact Mass ]:
190.099380

[ PSA ]:
26.30000

[ LogP ]:
2.63

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.545

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
22/23

[ Safety Phrases ]:
24/25

[ RIDADR ]:
2810

[ RTECS ]:
NP6810000

Related Compounds