Z-Ligustilide

Names

[ CAS No. ]:
81944-09-4

[ Name ]:
Z-Ligustilide

[Synonym ]:
Ligustilide A
Ligustilide
cis-ligustilide
Ligustilide, (Z)-
1(3H)-Isobenzofuranone, 3-butylidene-4,5-dihydro-, (3Z)-
Z-LIGUSTILIDE
(3Z)-3-Butylidene-4,5-dihydro-2-benzofuran-1(3H)-one

Biological Activity

[Description]:

(Z)-Ligustilide is extracted from Ligusticum chuanxiong Hort, has antimicrobial and antifungal activity, exhibits an average antifungal score of 5.6[1].(Z)-Ligustilide inhibits the expression of FATP5 and DGAT, inhibits fatty acid uptake and esterification in mice and has potential as therapeutics for nonalcoholic fatty liver disease (NAFLD) [2].

[Related Catalog]:

Research Areas >> Infection

Research Areas >> Metabolic Disease

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Rodrigues AMS, et al. The antifungal potential of (Z)-ligustilide and the protective effect of eugenol demonstrated by a chemometric approach. Sci Rep. 2019 Jun 19;9(1):8729. doi: 10.1038/s41598-019-45222-y

[2]. Ma H, et al. Z-ligustilide restores tamoxifen sensitivity of ERa negative breast cancer cells by reversing MTA1/IFI16/HDACs complex mediated epigenetic repression of ERa. Oncotarget. 2017 Apr 25;8(17):29328-29345.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
377.9±11.0 °C at 760 mmHg

[ Melting Point ]:
168～169℃

[ Molecular Formula ]:
C₁₂H₁₄O₂

[ Molecular Weight ]:
190.238

[ Flash Point ]:
158.6±16.7 °C

[ Exact Mass ]:
190.099380

[ PSA ]:
26.30000

[ LogP ]:
2.63

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.545

[ Storage condition ]:
2~8°C

Safety Information

[ Hazard Codes ]:
Xi

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.