81944-09-4

81944-09-4 structure

Name: Z-Ligustilide
Chemical Name: Ligustilide
CAS Number: 81944-09-4
Molecular Formula: C₁₂H₁₄O₂
Molecular Weight: 190.238
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-06-24 19:41:08
Modify Date: 2025-08-24 20:38:40
(Z)-Ligustilide is extracted from Ligusticum chuanxiong Hort, has antimicrobial and antifungal activity, exhibits an average antifungal score of 5.6[1].(Z)-Ligustilide inhibits the expression of FATP5 and DGAT, inhibits fatty acid uptake and esterification in mice and has potential as therapeutics for nonalcoholic fatty liver disease (NAFLD) [2].

Name	Ligustilide
Synonyms	Ligustilide A Ligustilide cis-ligustilide Ligustilide, (Z)- 1(3H)-Isobenzofuranone, 3-butylidene-4,5-dihydro-, (3Z)- Z-LIGUSTILIDE (3Z)-3-Butylidene-4,5-dihydro-2-benzofuran-1(3H)-one

Description	(Z)-Ligustilide is extracted from Ligusticum chuanxiong Hort, has antimicrobial and antifungal activity, exhibits an average antifungal score of 5.6[1].(Z)-Ligustilide inhibits the expression of FATP5 and DGAT, inhibits fatty acid uptake and esterification in mice and has potential as therapeutics for nonalcoholic fatty liver disease (NAFLD) [2].
Related Catalog	Research Areas >> Infection Research Areas >> Metabolic Disease Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Rodrigues AMS, et al. The antifungal potential of (Z)-ligustilide and the protective effect of eugenol demonstrated by a chemometric approach. Sci Rep. 2019 Jun 19;9(1):8729. doi: 10.1038/s41598-019-45222-y [2]. Ma H, et al. Z-ligustilide restores tamoxifen sensitivity of ERa negative breast cancer cells by reversing MTA1/IFI16/HDACs complex mediated epigenetic repression of ERa. Oncotarget. 2017 Apr 25;8(17):29328-29345.

Hazard Codes	Xi

Precursor 0
DownStream 1
88182-33-6