Levistilide A

Names

[ Name ]:
Levistilide A

[Synonym ]:
(1S,2S,6Z,10S,11S,16Z)-6,16-Dibutylidene-5,15-dioxapentacyclo[9.5.2.0.0.0]octadeca-3(7),12-diene-4,14-dione
diligustilide
1H-5,10c-Ethanonaphtho[1,2-c:7,8-c']difuran-3,10-dione, 1,8-dibutylidene-5,5a,6,7,8,10b-hexahydro-, (1Z,5S,5aS,8Z,10bS,10cS)-

Biological Activity

[Description]:

Levistolide A (LA), a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is used for treating cancer. Levistolide A can induce apoptosis via ROS-mediated ER stress pathway[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[References]

[1]. Yang Y,et al. Levistolide A Induces Apoptosis via ROS-Mediated ER Stress Pathway in Colon Cancer Cells. Cell Physiol Biochem 2017;42:929-938.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
623.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₂₈O₄

[ Molecular Weight ]:
380.477

[ Flash Point ]:
325.7±29.9 °C

[ Exact Mass ]:
380.198761

[ PSA ]:
52.60000

[ LogP ]:
5.11

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.596

Safety Information

[ Safety Phrases ]:
24/25

[ HS Code ]:
29322090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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