L(+)-Ornithine hydrochloride

Names

[ Name ]:
L(+)-Ornithine hydrochloride

[Synonym ]:
L-Ornithine, monohydrochloride
H-Orn-OH.HCl
L-Orn hydrochloride
(2S)-2,5-diaminopentanoic acid hydrochloride
L-Ornithine monohydrochloride
L-Ornithine HCl
(S)-2,5-Diaminovaleric acid monohydrochloride
D-ORNITHINE HCL
L(+)-Ornithinehydrochloride
H-Orn-OH·HCl
(S)-2,5-Diaminopentanoic acid monohydrochloride
D-ORN,HCL
MFCD00012917
H-D-ORN HCL
L-ORN HCL
ORNITHINE HCL
L(+)-Ornithine Hydrochloride
L-Ornithine hydrochloride (1:1)
H-L-ORN-OH HCL
Z3YZVQ &&L or S Form HCl
(S)-(+)-2,5-Diaminopentanoic acid hydrochloride
H-D-ORN-OH HCL
(S)-2,5-Diaminopentanoic acid hydrochloride
L-Ornithine, hydrochloride (1:1)
EINECS 240-729-3
L-ornithine hydrochloride
Guanine Hydrochloride

Biological Activity

[Description]:

L-Ornithine Hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.

[Related Catalog]:

Natural Products >> Others

Research Areas >> Metabolic Disease

[Target]

Human Endogenous Metabolite

[References]

[1]. Demura S, et al. Effect of L-ornithine hydrochloride ingestion on intermittent maximal anaerobic cycle ergometer performance and fatigue recovery after exercise. Eur J Appl Physiol. 2011 Nov;111(11):2837-43.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.57

[ Boiling Point ]:
308.7ºC at 760 mmHg

[ Melting Point ]:
245 °C (dec.)(lit.)

[ Molecular Formula ]:
C₅H₁₃ClN₂O₂

[ Molecular Weight ]:
168.622

[ Flash Point ]:
140.5ºC

[ Exact Mass ]:
168.066559

[ PSA ]:
89.34000

[ LogP ]:
1.33980

[ Index of Refraction ]:
24 ° (C=4, 6mol/L HCl)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RM2985000

CHEMICAL NAME :: Ornithine, monohydrochloride, L-

CAS REGISTRY NUMBER :: 3184-13-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C5-H12-N2-O2.Cl-H

MOLECULAR WEIGHT :: 168.65

WISWESSER LINE NOTATION :: Z3YZVQ &GH -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 62,49,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4776 No. of Facilities: 162 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 2955 (estimated) No. of Female Employees: 2312 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
RM2985000

[ HS Code ]:
2922499990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Preparation

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma.

Am. J. Respir. Cell. Mol. Biol. 48(6) , 694-702, (2013)

Up-regulation of arginase contributes to airways hyperresponsiveness (AHR) in asthma by reducing L-arginine bioavailability for the nitric oxide (NO) synthase isozymes. The product of arginase activit...

Microbacterium kyungheense sp. nov. and Microbacterium jejuense sp. nov., isolated from salty soil.

Int. J. Syst. Evol. Microbiol. 64(Pt 7) , 2267-73, (2014)

Two novel strains, THG-C26(T) and THG-C31(T), were characterized using a polyphasic approach to determine their taxonomic positions. These two isolates were aerobic, Gram-stain-positive, non-motile, n...

Treatment of arginase deficiency revisited: guanidinoacetate as a therapeutic target and biomarker for therapeutic monitoring.

Dev. Med. Child Neurol. 56(10) , 1021-4, (2014)

Hyperargininaemia is a disorder of the last step of the urea cycle. It is an autosomal recessive disease caused by deficiency of liver arginase-1 and usually presents later in childhood with progressi...