Captopril EP Impurity C

Names

[ Name ]:
Captopril EP Impurity C

[Synonym ]:
(2RS)-2-Methyl-3-sulphanylpropanoic acid 3-Mercaptoisobutyric acid
Captopril impurity C
EINECS 247-726-6
Propanoic acid, 3-mercapto-2-methyl-
3-sulfhydryl isobutyric acid
3-mercapto-2-methylpropionic acid
3-mercapto-2-methylpropanoic acid
3-Mercaptoisobutyric acid
MFCD00671555
UNII:V3E4016VAS
3-Mercapto-2-methyl propanoic acid
2-Methyl-3-sulfanylpropanoic acid
Captopril Impurity 3

Biological Activity

[Description]:

Captopril EP Impurity C is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM)[1][2][3].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. ANCA GABRIELA CÂRJE, et al. HPLC-UV METHOD APPROACH FOR THE ANALYSIS AND IMPURITY PROFILING OF CAPTOPRIL.

[2]. Afrin S, et al. Eritadenine from Edible Mushrooms Inhibits Activity of Angiotensin Converting Enzyme in Vitro. J Agric Food Chem. 2016;64(11):2263-2268.

[3]. Esmaeili S, et al. Captopril/enalapril inhibit promiscuous esterase activity of carbonic anhydrase at micromolar concentrations: An in vitro study. Chem Biol Interact. 2017;265:24-35.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
232.5±23.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄H₈O₂S

[ Molecular Weight ]:
120.170

[ Flash Point ]:
94.4±22.6 °C

[ Exact Mass ]:
120.024498

[ PSA ]:
76.10000

[ LogP ]:
0.78

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.491

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S26-S36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2930909090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

The utilization of 3-mercapto-2-methylpropionate as sulphur source by a phototrophic bacterium.

Bioorg. Med. Chem. 2(7) , 589-93, (1994)

A bacterium (strain photoB) photoassimilated 3-mercapto-2-methylpropionate as sole source of sulphur with methacrylate accumulating in the medium. This was thought to be the product of a sulphur-lyase...

Bacterial taxa that limit sulfur flux from the ocean.

Science 314(5799) , 649-52, (2006)

Flux of dimethylsulfide (DMS) from ocean surface waters is the predominant natural source of sulfur to the atmosphere and influences climate by aerosol formation. Marine bacterioplankton regulate sulf...

Methylthiol:coenzyme M methyltransferase from Methanosarcina barkeri, an enzyme of methanogenesis from dimethylsulfide and methylmercaptopropionate.

J. Bacteriol. 179(22) , 6902-11, (1997)

During growth on acetate, Methanosarcina barkeri expresses catabolic enzymes for other methanogenic substrates such as monomethylamine. The range of substrates used by cells grown on acetate was furth...

Related Compounds

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