Methacrylic acid

Names

[ CAS No. ]:
79-41-4

[ Name ]:
Methacrylic acid

[Synonym ]:
Loctite3298
2-methylprop-2-enoic acid
FX668F
a-Methylacrylic Acid
Methacrylic acid
acidometacrilico
2-Propenoic acid, 2-methyl-
CH2=C(CH3)COOH
METAACRYLIC ACID
EINECS 201-204-4
2-methylpropenoic acid
2-Methylene propionic acid
2-Propenoic acid, 2-methyl-, endo-
2-methylacrylic acid
acidemethacrylique
(methyl)acrylic acid
GE110
methylcrotonic acid
MFCD00002651

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
160.5±0.0 °C at 760 mmHg

[ Melting Point ]:
16 °C

[ Molecular Formula ]:
C₄H₆O₂

[ Molecular Weight ]:
86.089

[ Flash Point ]:
76.7±0.0 °C

[ Exact Mass ]:
86.036781

[ PSA ]:
37.30000

[ LogP ]:
0.83

[ Vapour density ]:
>3 (vs air)

[ Vapour Pressure ]:
1.2±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.430

[ Stability ]:
May be stabilized by the addition of MEHQ (Hydroquinone methyl ether, ca. 250 ppm) or hydroquinone. In the absence of a stabilizer this material will readily polymerize. Combustible. Incompatible with strong oxidizing agents, hydrochloric acid.

[ Water Solubility ]:
9.7 g/100 mL (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OZ2975000

CHEMICAL NAME :: Methacrylic acid

CAS REGISTRY NUMBER :: 79-41-4

BEILSTEIN REFERENCE NO. :: 1719937

LAST UPDATED :: 199712

DATA ITEMS CITED :: 34

MOLECULAR FORMULA :: C4-H6-O2

MOLECULAR WEIGHT :: 86.10

WISWESSER LINE NOTATION :: QVY1&U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1060 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 48 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 95200 nL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 910 mg/kg/26W-I

TOXIC EFFECTS :: Behavioral - alteration of classical conditioning

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 221 mg/m3/24H/17W-C

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 221 mg/m3/24H/17W-C

TOXIC EFFECTS :: Behavioral - alteration of classical conditioning

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 910 mg/kg/26W-I

TOXIC EFFECTS :: Liver - liver function tests impaired Nutritional and Gross Metabolic - metabolic acidosis

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Bacteria - Escherichia coli

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981 *** REVIEWS *** ACGIH TLV-TWA 70 mg/m3 (20 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 11,141,1975 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 20 ppm (70 mg/m3) JAN 1993 OEL-BELGIUM:TWA 20 ppm (70 mg/m3) JAN 1993 OEL-DENMARK:TWA 20 ppm (70 mg/m3) JAN 1993 OEL-FRANCE:TWA 20 ppm (70 mg/m3) JAN 1993 OEL-GERMANY:TWA 50 ppm (210 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 20 ppm (70 mg/m3) JAN 1993 OEL-RUSSIA:STEL 101 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 20 ppm (70 mg/m3);STEL 30 ppm (100 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 20 ppm (70 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 20 ppm (70 mg/m3);STEL 40 ppm (140 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO METHACRYLIC ACID-air:10H TWA 20 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3304 No. of Facilities: 1529 (estimated) No. of Industries: 12 No. of Occupations: 31 No. of Employees: 18977 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M3304 No. of Facilities: 10110 (estimated) No. of Industries: 109 No. of Occupations: 75 No. of Employees: 145414 (estimated) No. of Female Employees: 46453 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302 + H332-H311-H314-H335

[ Precautionary Statements ]:
P261-P280-P301 + P312 + P330-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive

[ Risk Phrases ]:
R21/22;R35

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 2531 8/PG 2

[ WGK Germany ]:
1

[ RTECS ]:
OZ2975000

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
2916130010

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2916130010

[ Summary ]:
HS: 2916130010. methacrylic acid. VAT:17.0%. tax rebate rate:13.0%. supervision conditions:ab(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tarrif:6.5%. general tariff:80.0%

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Related Compounds

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