Ethyl methacrylate
Names
[ CAS No. ]:
97-63-2
[ Name ]:
Ethyl methacrylate
[Synonym ]:
Methacrylic acid-ethyl ester
ethyl2-methacrylate
2-METHYL-ACRYLIC ACID ETHYL ESTER
RARECHEM AL BI 0124
MFCD00009161
Ethylmethacrylat
2-Propenoic acid, 2-methyl-, ethyl ester
Ethyl 2-methyl-2-propenoate
Ethyl methacrylate
ethyl 2-methylpropenoate
Ethylmethylacryate
2OVY1&U1
Ethyl methylacrylate
Ethylmethacrylate
EMA
EINECS 202-597-5
Rhoplex ac-33
Ethyl-2-methylprop-2-enoat
2-PROPENOIC ACID,2-METHYL-, ETHYL ESTER
Chemical & Physical Properties
[ Density]:
0.9±0.1 g/cm3
[ Boiling Point ]:
120.5±9.0 °C at 760 mmHg
[ Melting Point ]:
-75 °C
[ Molecular Formula ]:
C6H10O2
[ Molecular Weight ]:
114.142
[ Flash Point ]:
15.6±0.0 °C
[ Exact Mass ]:
114.068077
[ PSA ]:
26.30000
[ LogP ]:
1.88
[ Vapour density ]:
>3.9 (vs air)
[ Vapour Pressure ]:
15.2±0.2 mmHg at 25°C
[ Index of Refraction ]:
1.410
[ Stability ]:
Polymerizes in the presence of light or heat. Incompatible with peroxides, oxidizing agents, bases, acids, reducing agents, halogens and amines. Flammable.
[ Water Solubility ]:
4 g/L (20 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OZ4550000
- CHEMICAL NAME :
- Methacrylic acid, ethyl ester
- CAS REGISTRY NUMBER :
- 97-63-2
- BEILSTEIN REFERENCE NO. :
- 0471201
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 23
- MOLECULAR FORMULA :
- C6-H10-O2
- MOLECULAR WEIGHT :
- 114.16
- WISWESSER LINE NOTATION :
- 2OVY1&U1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 14800 mg/kg
- TOXIC EFFECTS :
- Behavioral - muscle weakness Behavioral - coma Lungs, Thorax, or Respiration - respiratory depression
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 8300 ppm/4H
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1223 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 25 gm/kg
- TOXIC EFFECTS :
- Behavioral - muscle weakness Behavioral - coma Lungs, Thorax, or Respiration - respiratory depression
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 7836 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1369 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 137 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 3630 mg/kg
- TOXIC EFFECTS :
- Behavioral - muscle weakness Behavioral - coma Lungs, Thorax, or Respiration - respiratory depression
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >10 mL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 735 mg/kg
- SEX/DURATION :
- female 5-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 366 mg/kg
- SEX/DURATION :
- female 5-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - mouse Lymphocyte
- DOSE/DURATION :
- 1450 mg/L
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 11,49,1988 *** REVIEWS *** TOXICOLOGY REVIEW EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 11,141,1975 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 50 mg/m3 JAN 1993 OEL-SWEDEN:TWA 50 ppm (250 mg/m3);STEL 75 ppm (350 mg/m3) JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5843 No. of Facilities: 259 (estimated) No. of Industries: 3 No. of Occupations: 7 No. of Employees: 4644 (estimated) No. of Female Employees: 1584 (estimated)
Safety Information
[ Symbol ]:
GHS02, GHS07
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H315-H317-H319-H335
[ Precautionary Statements ]:
P210-P261-P280-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
F:Flammable;Xi:Irritant;
[ Risk Phrases ]:
R11;R36/37/38;R43
[ Safety Phrases ]:
S9-S16-S29-S33
[ RIDADR ]:
UN 2277 3/PG 2
[ WGK Germany ]:
1
[ RTECS ]:
OZ4550000
[ Packaging Group ]:
II
[ Hazard Class ]:
3
[ HS Code ]:
2916140000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2916140000
[ Summary ]:
2916140000. other esters of methacrylic acid. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:80.0%
Articles
Macromol. Biosci. 15 , 965-78, (2015)
A novel gene transfection vector was fabricated based on the conjugation of human serum albumin (HSA) and maleimide end functionalized poly[(N,N-dimethylamino) ethyl methacrylate] (PDMAEMA). The bioco...
Preparation and application of sol-gel acrylate and methacrylate solid-phase microextraction fibres for gas chromatographic analysis of organoarsenic compounds.Anal. Chim. Acta 837 , 52-63, (2014)
Novel solid-phase microextraction (SPME) fibres containing methyl, ethyl, butyl acrylate and methacrylate were first prepared by a sol-gel technique and investigated for determination of selected orga...
UV-curable gel formulations: Potential drug carriers for the topical treatment of nail diseases.Int. J. Pharm. 492 , 177-90, (2015)
Nail diseases are common, cause significant distress and treatments are far from successful. Our aim was to investigate the potential of UV-curable gels - currently used as cosmetics - as topical drug...