Bempedoic acid-d4

Names

[ CAS No. ]:
2408131-70-2

[ Name ]:
Bempedoic acid-d4

Biological Activity

[Description]:

Bempedoic acid-d4 is the deuterium labeled Bempedoic acid. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor. Bempedoic acid (ETC-1002) activates AMPK[1][2].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> AMPK
Research Areas >> Others
Signaling Pathways >> Metabolic Enzyme/Protease >> ATP Citrate Lyase
Signaling Pathways >> PI3K/Akt/mTOR >> AMPK

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[3].

[References]

[1]. Pinkosky SL, et al. AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism. J Lipid Res. 2013 Jan;54(1):134-51.  

[2]. Filippov S, et al. ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK. J Lipid Res. 2013 Aug;54(8):2095-108.  

[3]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  

Chemical & Physical Properties

[ Molecular Formula ]:
C19H32D4O5

[ Molecular Weight ]:
348.51

Related Compounds