2408131-70-2

2408131-70-2 structure

2408131-70-2 structure

Name: Bempedoic acid-d4
Chemical Name: Bempedoic acid-d4
CAS Number: 2408131-70-2
Molecular Formula: C₁₉H₃₂D₄O₅
Molecular Weight: 348.51
Catalog: Signaling Pathways Epigenetics AMPK
Create Date: 2023-01-14 17:55:03
Modify Date: 2024-01-07 11:35:50
Bempedoic acid-d4 is the deuterium labeled Bempedoic acid. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor. Bempedoic acid (ETC-1002) activates AMPK[1][2].

Name	Bempedoic acid-d4

Description	Bempedoic acid-d4 is the deuterium labeled Bempedoic acid. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor. Bempedoic acid (ETC-1002) activates AMPK[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> AMPK Research Areas >> Others Signaling Pathways >> Metabolic Enzyme/Protease >> ATP Citrate Lyase Signaling Pathways >> PI3K/Akt/mTOR >> AMPK
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[3].
References	[1]. Pinkosky SL, et al. AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism. J Lipid Res. 2013 Jan;54(1):134-51. [2]. Filippov S, et al. ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK. J Lipid Res. 2013 Aug;54(8):2095-108. [3]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Molecular Formula	C₁₉H₃₂D₄O₅
Molecular Weight	348.51