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Taurocholic Acid-d4

Names

[ CAS No. ]:
252030-90-3

[ Name ]:
Taurocholic Acid-d4

[Synonym ]:
d4-TC
2-[[(3|A,5|A,7|A,12|A)-3,7,12-trihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]amino]ethanesulfonic Acid

Biological Activity

[Description]:

Taurocholic acid-d4 is deuterium labeled Taurocholic acid. Taurocholic acid (N-Choloyltaurine) is a bile acid involved in the emulsification of fats.

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Mooranian A, et al. The effect of a tertiary bile acid, taurocholic acid, on the morphology and physical characteristics of microencapsulated probucol: potential applications in diabetes: a characterization study. Drug Deliv Transl Res. 2015 Oct;5(5):511-22.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H41D4NO7S

[ Molecular Weight ]:
519.73

[ Exact Mass ]:
519.31700

[ PSA ]:
156.03000

[ LogP ]:
4.28920

Related Compounds