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1,3,5-Tri-O-benzoyl-α-D-ribofuranose

Names

[ CAS No. ]:
22224-41-5

[ Name ]:
1,3,5-Tri-O-benzoyl-α-D-ribofuranose

[Synonym ]:
α-D-Ribofuranose, 1,3,5-tribenzoate
1,3,5-Tri-O-benzoyl-a-D-ribofuranose
MFCD00080818
1,3,5-Tri-O-benzoyl-α-d-ribofuranose
a-D-Ribofuranose,1,3,5-tribenzoate
1,3,5-TRIBENZOYL-A-D-RIBOFURANOSE
1,3,5-tribenzoate-a-D-Ribofuranose

Biological Activity

[Description]:

1,3,5-Tri-O-benzoyl-a-D-ribofuranose is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
629.6±55.0 °C at 760 mmHg

[ Melting Point ]:
125-129 °C(lit.)

[ Molecular Formula ]:
C26H22O8

[ Molecular Weight ]:
462.45

[ Flash Point ]:
213.0±25.0 °C

[ Exact Mass ]:
462.131470

[ PSA ]:
108.36000

[ LogP ]:
6.12

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.633

[ Storage condition ]:
2~8 ℃

MSDS

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Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S22-S24/25

[ WGK Germany ]:
3

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds