(±)-nicotine
Names
[ CAS No. ]:
22083-74-5
[ Name ]:
(±)-nicotine
[Synonym ]:
vrzjvuppqwdfac-yhyxmxqvsa
(R,S)-nicotine
(RS)-nicotine
3-(1-Methyl-2-pyrrolidinyl)pyridine
fdhr
3-(1-methyl-2-pyrrolidinyl)-Pyridine
1-Methyl-2-(3-pyridyl)pyrrolidine
MFCD00065370
(+/-)-nicotine
Pyridine, 3-(1-methyl-2-pyrrolidinyl)-
Pyridine, 3-(1-methyl-2-pyrrolidinyl)- (9CI)
(±)-3-(1-Methyl-2-pyrrolidinyl)pyridine
DL-Nicotine
(±)-nicotine
3-(1-Methylpyrrolidin-2-yl)pyridine
Nicotine
Chemical & Physical Properties
[ Density]:
1.0±0.1 g/cm3
[ Boiling Point ]:
244.4±28.0 °C at 760 mmHg
[ Melting Point ]:
-79ºC
[ Molecular Formula ]:
C10H14N2
[ Molecular Weight ]:
162.232
[ Flash Point ]:
101.7±0.0 °C
[ Exact Mass ]:
162.115692
[ PSA ]:
16.13000
[ LogP ]:
0.72
[ Appearance of Characters ]:
liquid | yellow
[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C
[ Index of Refraction ]:
1.539
[ Storage condition ]:
Refrigerator
[ Water Solubility ]:
ethanol: 50 mg/mL
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QS5257500
- CHEMICAL NAME :
- Nicotine, (+-)-
- CAS REGISTRY NUMBER :
- 22083-74-5
- BEILSTEIN REFERENCE NO. :
- 0082111
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C10-H14-N2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 31250 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 50,93,1934
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 50,93,1934
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 2 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 50,93,1934
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 15 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 50,93,1934
Safety Information
[ Symbol ]:
GHS06, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301-H310-H411
[ Precautionary Statements ]:
P273-P280-P301 + P310-P302 + P350-P310
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
T+: Very toxic;N: Dangerous for the environment;
[ Risk Phrases ]:
25-27-51/53
[ Safety Phrases ]:
36/37-45-61
[ RIDADR ]:
UN 1654 6.1/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
QS5257500
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Eur. J. Neurosci. 41(1) , 109-19, (2015)
Rats raised in an enriched condition (EC) exhibit alterations in the neurobiological and behavioral response to nicotine compared with rats reared in an impoverished condition (IC) or a standard condi...
Effects of maternal nicotine exposure on thyroid hormone metabolism and function in adult rat progeny.J. Endocrinol. 224(3) , 315-25, (2015)
Postnatal nicotine exposure leads to obesity and hypothyroidism in adulthood. We studied the effects of maternal nicotine exposure during lactation on thyroid hormone (TH) metabolism and function in a...
A critical role for the melanocortin 4 receptor in stress-induced relapse to nicotine seeking in rats.Addict. Biol. 20(2) , 324-35, (2015)
Tobacco addiction is characterized by a lack of control over smoking and relapse after periods of abstinence. Smoking cessation leads to a dysphoric state that contributes to relapse to smoking. After...