(±)-nicotine

Modify Date: 2024-01-03 01:16:21

(±)-nicotine structure	Common Name	(±)-nicotine
	CAS Number	22083-74-5	Molecular Weight	162.232
	Density	1.0±0.1 g/cm3	Boiling Point	244.4±28.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₄N₂	Melting Point	-79ºC
	MSDS	Chinese USA	Flash Point	101.7±0.0 °C
	Symbol	GHS06, GHS09	Signal Word	Danger

Name	nicotine
Synonym	More Synonyms

Density	1.0±0.1 g/cm3
Boiling Point	244.4±28.0 °C at 760 mmHg
Melting Point	-79ºC
Molecular Formula	C₁₀H₁₄N₂
Molecular Weight	162.232
Flash Point	101.7±0.0 °C
Exact Mass	162.115692
PSA	16.13000
LogP	0.72
Appearance of Characters	liquid \| yellow
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.539
Storage condition	Refrigerator
Water Solubility	ethanol: 50 mg/mL

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QS5257500

CHEMICAL NAME :: Nicotine, (+-)-

CAS REGISTRY NUMBER :: 22083-74-5

BEILSTEIN REFERENCE NO. :: 0082111

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H14-N2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 31250 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 50,93,1934

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 50,93,1934

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 50,93,1934

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 50,93,1934

Symbol	GHS06, GHS09
Signal Word	Danger
Hazard Statements	H301-H310-H411
Precautionary Statements	P273-P280-P301 + P310-P302 + P350-P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	T+: Very toxic;N: Dangerous for the environment;
Risk Phrases	25-27-51/53
Safety Phrases	36/37-45-61
RIDADR	UN 1654 6.1/PG 2
WGK Germany	3
RTECS	QS5257500

Precursor 8
CAS#:50-00-0 Formaldehyde CAS#:5746-86-1 (±)-Nornicotine CAS#:64-18-6 Formic Acid CAS#:25162-00-9 (+)-Nicotine
CAS#:125630-28-6 (R,S)-1-METHYL-... CAS#:74-89-5 methylamine CAS#:76014-80-7 4-oxo-4-(3-pyri... CAS#:180407-32-3 (RS) 1-methyl-2...
DownStream 9
CAS#:74-89-5 methylamine CAS#:487-19-4 3-(1-Methyl-1H-... CAS#:120-94-5 1-Methylpyrrolidine CAS#:54-11-5 L-Nicotine
CAS#:25162-00-9 (+)-Nicotine CAS#:532-12-7 Myosmine CAS#:15569-85-4 1-Methyl-5-(3-p... CAS#:89100-79-8 Pyridine, 3-(3,...
CAS#:5746-86-1 (±)-Nornicotine

Effects of environmental enrichment on ERK1/2 phosphorylation in the rat prefrontal cortex following nicotine-induced sensitization or nicotine self-administration.

Eur. J. Neurosci. 41(1) , 109-19, (2015)

Rats raised in an enriched condition (EC) exhibit alterations in the neurobiological and behavioral response to nicotine compared with rats reared in an impoverished condition (IC) or a standard condi...

Effects of maternal nicotine exposure on thyroid hormone metabolism and function in adult rat progeny.

J. Endocrinol. 224(3) , 315-25, (2015)

Postnatal nicotine exposure leads to obesity and hypothyroidism in adulthood. We studied the effects of maternal nicotine exposure during lactation on thyroid hormone (TH) metabolism and function in a...

A critical role for the melanocortin 4 receptor in stress-induced relapse to nicotine seeking in rats.

Addict. Biol. 20(2) , 324-35, (2015)

Tobacco addiction is characterized by a lack of control over smoking and relapse after periods of abstinence. Smoking cessation leads to a dysphoric state that contributes to relapse to smoking. After...

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(R,S)-nicotine

(RS)-nicotine

3-(1-Methyl-2-pyrrolidinyl)pyridine

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3-(1-methyl-2-pyrrolidinyl)-Pyridine

1-Methyl-2-(3-pyridyl)pyrrolidine

MFCD00065370

(+/-)-nicotine

Pyridine, 3-(1-methyl-2-pyrrolidinyl)-

Pyridine, 3-(1-methyl-2-pyrrolidinyl)- (9CI)

(±)-3-(1-Methyl-2-pyrrolidinyl)pyridine

DL-Nicotine

(±)-nicotine

3-(1-Methylpyrrolidin-2-yl)pyridine

Nicotine

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (+/-)-Nicotine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Pyridine,3-(1-methyl-2-pyrrolidinyl)-
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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(±)-nicotine

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