(±)-Nornicotine
Names
[ CAS No. ]:
5746-86-1
[ Name ]:
(±)-Nornicotine
[Synonym ]:
3-pyrrolidin-2-yl-pyridine
EINECS 200-659-6
NORNICOTINE,DL
2-[3-PYRIDYL]PYRROLIDINE
(+/-)-nor-nicotine
(2S)-2-(3-Pyridinyl)pyrrolidinium
2-(3-pyridyl)pyrollidine
MFCD00016913
2-[3-PYRIDYL]PYRROLIDONE
DL-NORNICOTINE
2-(3-Pyridinyl)pyrrolidine
(R,S)-NORNICOTINE
Pyrrolidinium, 2-(3-pyridinyl)-, (2S)-
Biological Activity
[Description]:
[Target]
Human Endogenous Metabolite
Chemical & Physical Properties
[ Density]:
1,074 g/cm3
[ Boiling Point ]:
107-108°C 2mm
[ Molecular Formula ]:
C9H12N2
[ Molecular Weight ]:
148.20500
[ Flash Point ]:
101°C
[ Exact Mass ]:
148.10000
[ PSA ]:
24.92000
[ LogP ]:
1.83490
[ Index of Refraction ]:
1.54
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
H2O: 50 mg/mL
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QS6350000
- CHEMICAL NAME :
- Nicotine, 1'-demethyl-, (+-)-
- CAS REGISTRY NUMBER :
- 5746-86-1
- LAST UPDATED :
- 199206
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C9-H12-N2
- MOLECULAR WEIGHT :
- 148.23
- WISWESSER LINE NOTATION :
- T6NJ C- BT5MTJ -+-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 18750 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 50,93,1934
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 50,93,1934
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 900 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 50,93,1934
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 50,93,1934
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335
[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R20/21/22;R36/37/38
[ Safety Phrases ]:
S26-S36/37
[ RIDADR ]:
2810
[ WGK Germany ]:
3
[ RTECS ]:
QS6350000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1
[ HS Code ]:
2933990090
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Bioorg. Med. Chem. Lett. 15 , 877-81, (2005)
6'-Methylpyrido[3,4-b]norhomotropane [synthesis as the racemate reported here] is more potent at the alpha4beta2 nicotinic receptor than any previous bridged nicotinoid. The two nitrogens and 6'-methy...
3-(2-Aminoethyl)pyridine analogs as alpha4beta2 nicotinic cholinergic receptor ligands.Bioorg. Med. Chem. Lett. 15 , 4308-12, (2005)
An examination of several 3-(2-aminoethyl)pyridine analogs suggests that they likely orient at alpha4beta2 nicotinic cholinergic receptors in a different fashion than their correspondingly substituted...
Abuse potential of non-nicotine tobacco smoke components: acetaldehyde, nornicotine, cotinine, and anabasine.Nicotine Tob. Res. 15(3) , 622-32, (2013)
This review identified published animal studies evaluating the possible abuse potential of acetaldehyde, nornicotine, cotinine, and anabasine based on five commonly used paradigms. These include their...