CX-157

Names

[ CAS No. ]:
205187-53-7

[ Name ]:
CX-157

[Synonym ]:
Phenoxathiin,3-fluoro-7-(2,2,2-trifluoroethoxy)-,10,10-dioxide
CX157
CX-157

Biological Activity

[Description]:

CX-157 is a reversible inhibitor of monoamine oxidase-A (MAO-A) with an EC50 of 19.3 ng/mL.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase
Research Areas >> Neurological Disease

[Target]

EC50: 19.3 ng/mL (MAO-A)[1]


[In Vivo]

CX-157 is a reversible inhibitor of monoamine oxidase-A (MAO-A) with an EC50 of 19.3 ng/mL. CX-157 is an investigational compound currently in development for the treatment of major depressive disorder (MDD). Mechanistic studies in animals have shown that CX-157 acts to inhibit MAO-A activity in a reversible and competitive manner, elevating brain levels of monoamine neurotransmitters[1].

[References]

[1]. Fowler JS, et al. Reversible inhibitors of monoamine oxidase-A (RIMAs): robust, reversible inhibition of human brain MAO-A by CX157. Neuropsychopharmacology. 2010 Feb;35(3):623-31.


[Related Small Molecules]

Phenelzine (sulfate) | trans-2-Phenylcyclopropylamine hemisulfate salt | Clorgyline hydrochloride | Rosmarinic acid | pargyline hydrochloride | GSK-LSD1 Dihydrochloride | Rasagiline mesylate | Mofegiline hydrochloride | Paeonol | Iproniazid (phosphate) | Safinamide | TVP1022 | Minaprine | Nialamide | Desmethoxyyangonin

Chemical & Physical Properties

[ Molecular Formula ]:
C14H8F4O4S

[ Molecular Weight ]:
348.27000

[ Exact Mass ]:
348.00800

[ PSA ]:
60.98000

[ LogP ]:
4.78610

[ Storage condition ]:
2-8℃

Related Compounds