CX 717
Names
[ CAS No. ]:
867276-98-0
[ Name ]:
CX 717
[Synonym ]:
2,1,3-Benzoxadiazol-5-yl(4-morpholinyl)methanone
Methanone, 2,1,3-benzoxadiazol-5-yl-4-morpholinyl-
Biological Activity
[Description]:
CX 717 is a positive allosteric modulator of AMPA receptor. Antidepressant-like effect. CX 717 can be used for the research of adult attention deficit hyperactivity disorder (ADHD)[1][2].
[Related Catalog]:
[In Vivo]
CX 717 (CX717; 20 mg/kg) has a rapid (30 min) but short-lasting (up to 24 h) antidepressantlike effect in the forced swim test.CX 717 also produces a rapid (up to 1 h) increase of brain-derived neurotrophic factor (BDNF) and a more sustained (up to 6 h) increase of p11[2]. Intra-cortical infusion of CX 717 (85 mM) increases the efflux of noradrenaline, dopamine, and serotonin, but not glutamate[2]. Animal Model: Male Sprague-Dawley rats weighing 280-350 g[2] Dosage: 20 mg/kg (administered at 1 mL/kg) Administration: Intraperitoneal (i.p.) injection Result: Evoked antidepressant-like effects (20 mg/kg, i.p.) did not alter the extracellular concentrations of noradrenaline (NA), dopamine (DA), serotonin (5-HT) and glutamate in the medial prefrontal cortex (mPFC).
[References]
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
422.1±55.0 °C at 760 mmHg
[ Molecular Formula ]:
C11H11N3O3
[ Molecular Weight ]:
233.223
[ Flash Point ]:
209.1±31.5 °C
[ Exact Mass ]:
233.080048
[ LogP ]:
-0.64
[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C
[ Index of Refraction ]:
1.623