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CX 4338

Names

[ CAS No. ]:
41609-06-7

[ Name ]:
CX 4338

[Synonym ]:
MFCD00170629
1-Cyclohexene-1-carbothioamide, 4,4-dimethyl-6-oxo-N-phenyl-2-[(phenylmethyl)amino]-
2-(benzylamino)-4,4-dimethyl-6-oxo-N-phenylcyclohex-1-ene-1-carbothioamide
2-(Benzylamino)-4,4-dimethyl-6-oxo-N-phenyl-1-cyclohexene-1-carbothioamide

Biological Activity

[Description]:

CX 4338 (CX4338, CX-4338) is a potent, selective CXCR2 inhibitor that selectively inhibits CXCR2-mediated recruitment of β-arrestin-2 with IC50 of 6.3 uM; shows little to no inhibition of CXCR4-mediated β-arrestin-2 recruitment at 100 uM; inhibits receptor internalization, while enhancing CXCR2-mediated MAPK activation; inhibits CXCL8-induced chemotaxis in CXCR2-overexpressing cells and human neutrophils; significantly reduces neutrophils in bronchoalveolar lavage induced by LPS in mice.

[References]

References 1. Ha H, et al. Br J Pharmacol. 2014 Mar;171(6):1551-65. View Related Products by Target Chemokine Receptor (CCR and CXCR)

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
511.1±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H24N2OS

[ Molecular Weight ]:
364.504

[ Flash Point ]:
262.9±32.9 °C

[ Exact Mass ]:
364.160919

[ LogP ]:
4.85

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.638

Safety Information

[ Symbol ]:

GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H410

[ Precautionary Statements ]:
P273-P501

[ RIDADR ]:
UN 3077 9 / PGIII

Related Compounds